ArticleThe American journal of psychiatry2023
Maternal Perinatal Stress Trajectories and Negative Affect and Amygdala Development in Offspring.
Open access · greenAbstract read
In one paragraph
Article in The American journal of psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
9.0field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- Maternal psychological distress, breast milk extracellular vesicles, and infant immunity: A translational study.Brain, behavior, & immunity - health · 2026Article
- Postnatal distress, neonatal cerebellar myelination and neurodevelopmental outcomes at 18 months.Molecular psychiatry · 2026Article
- Functional brain connectivity from the fetal period through infancy: A narrative review of resting-state fMRI studies.Developmental cognitive neuroscience · 2026Review
- Maternal Stress During Pregnancy Induces Higher Anxiety-Like Behavior in Male Mice Offspring Under Acute Stress by Upregulating CRF/CRFR1 and Driving Time-Specific Activation of the MHb-IPN Circuit.Neuroscience bulletin · 2026Article
- Prenatal experience of greater neighborhood disadvantage is associated with altered fetal volumetric brain growth in utero.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Early-life neural correlates of behavioral inhibition and anxiety risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Prenatal antidepressant exposure is associated withFrontiers in neuroscience · 2026Article
- A Nomogram Predicting the Risk of Anxiety in Third-Trimester pregnancy in Pregnant Women with CTDs.Journal of multidisciplinary healthcare · 2026Article
- Prevalence and risk factors of postpartum depression, anxiety, and comorbidity of both disorders: a cross-sectional study.BMC pregnancy and childbirth · 2025Article
- The role of perinatal perceived stress in the setting of adverse childhood experience and perinatal anxiety and depressive symptoms.BMC psychology · 2025Article
- Psychometric validation of the Chinese version of the perceived stress scale-10 among pregnant women.BMC psychology · 2025Article
- Identifying subtypes based on environmental and neurobiological risk and resilience factors of postpartum maternal mental health.Translational psychiatry · 2025Article
- Cortisol as a Mediator of Prenatal Distress and Difficult Infant Temperament: A Systematic Review and Meta-Analysis Protocol.Health science reports · 2025Article
- Pre- and postnatal maternal depressive symptoms associated with local connectivity of the left amygdala in 5-year-olds.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Emotional Brain Development: Neurobiological Indicators from Fetus Through Toddlerhood.Brain sciences · 2025Article
- Major Factors Contributing to Positive and Negative Childbirth Experiences in Pregnant Women Living with HIV.Behavioral sciences (Basel, Switzerland) · 2025Article
- Perinatal intrusions: A window into perinatal anxiety disorders.Science advances · 2025Review
- Prenatal Antidepressant Exposure and the Developing Brain: A Review of Neuroimaging Findings.Current topics in behavioral neurosciences · 2025Review
- Havening: a psycho-sensory therapy for enhancing emotional resilience and psycho-emotional wellbeing across the perinatal period.Frontiers in global women's health · 2025Article
- Prenatal Stress and Maternal Role in Neurodevelopment.Annual review of developmental psychology · 2024Article
Corrections and comments
- Commented on by
Authors and funding
17 authors at 1 institution in 1 country.
Mollie C MarrDepartment of Behavioral Neuroscience (Marr, Graham, Sturgeon, Schifsky, Fair) and Department of Psychiatry (Graham, Fair), Oregon Health and Science University School of Medicine, Portland; Department of Psychiatry, Massachusetts General Hospital, Boston (Marr); Department of Psychiatry, McLean Hospital, Belmont, Mass. (Marr); Masonic Institute for the Developing Brain, Institute of Child Development (Fair), and Department of Pediatrics (Feczko, Fair), University of Minnesota, Minneapolis; Department of Psychology and Speech-Language Pathology, University of Turku, Turku, Finland (Nolvi, Korja); Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin (Nolvi, Entringer, Buss); Department of Neuroscience, Earlham College, Richmond, Ind. (Thomas); Development, Health, and Disease Research Program and Departments of Pediatrics, Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Irvine (Rasmussen, Entringer, Wadhwa, Buss); Department of Pediatrics, University of California, Irvine, School of Medicine, Orange (Rasmussen, Entringer, Wadhwa, Buss); Departments of Psychiatry and Human Behavior (Entringer, Wadhwa), Obstetrics and Gynecology (Wadhwa), and Epidemiology (Wadhwa), University of California, Irvine, School of Medicine, Orange; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku (Korja, H. Karlsson, L. Karlsson); Centre for Population Health Research, University of Turku and Turku University Hospital (Korja, H. Karlsson, L. Karlsson); Department of Paediatrics and Adolescent Medicine (L. Karlsson) and Department of Psychiatry (H. Karlsson), Department of Clinical Medicine, Turku University Hospital and University of Turku; Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill (Gilmore); Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill (Styner).
Alice M GrahamDepartment of Behavioral Neuroscience (Marr, Graham, Sturgeon, Schifsky, Fair) and Department of Psychiatry (Graham, Fair), Oregon Health and Science University School of Medicine, Portland; Department of Psychiatry, Massachusetts General Hospital, Boston (Marr); Department of Psychiatry, McLean Hospital, Belmont, Mass. (Marr); Masonic Institute for the Developing Brain, Institute of Child Development (Fair), and Department of Pediatrics (Feczko, Fair), University of Minnesota, Minneapolis; Department of Psychology and Speech-Language Pathology, University of Turku, Turku, Finland (Nolvi, Korja); Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin (Nolvi, Entringer, Buss); Department of Neuroscience, Earlham College, Richmond, Ind. (Thomas); Development, Health, and Disease Research Program and Departments of Pediatrics, Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Irvine (Rasmussen, Entringer, Wadhwa, Buss); Department of Pediatrics, University of California, Irvine, School of Medicine, Orange (Rasmussen, Entringer, Wadhwa, Buss); Departments of Psychiatry and Human Behavior (Entringer, Wadhwa), Obstetrics and Gynecology (Wadhwa), and Epidemiology (Wadhwa), University of California, Irvine, School of Medicine, Orange; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku (Korja, H. Karlsson, L. Karlsson); Centre for Population Health Research, University of Turku and Turku University Hospital (Korja, H. Karlsson, L. Karlsson); Department of Paediatrics and Adolescent Medicine (L. Karlsson) and Department of Psychiatry (H. Karlsson), Department of Clinical Medicine, Turku University Hospital and University of Turku; Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill (Gilmore); Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill (Styner).
Eric FeczkoDepartment of Behavioral Neuroscience (Marr, Graham, Sturgeon, Schifsky, Fair) and Department of Psychiatry (Graham, Fair), Oregon Health and Science University School of Medicine, Portland; Department of Psychiatry, Massachusetts General Hospital, Boston (Marr); Department of Psychiatry, McLean Hospital, Belmont, Mass. (Marr); Masonic Institute for the Developing Brain, Institute of Child Development (Fair), and Department of Pediatrics (Feczko, Fair), University of Minnesota, Minneapolis; Department of Psychology and Speech-Language Pathology, University of Turku, Turku, Finland (Nolvi, Korja); Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin (Nolvi, Entringer, Buss); Department of Neuroscience, Earlham College, Richmond, Ind. (Thomas); Development, Health, and Disease Research Program and Departments of Pediatrics, Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Irvine (Rasmussen, Entringer, Wadhwa, Buss); Department of Pediatrics, University of California, Irvine, School of Medicine, Orange (Rasmussen, Entringer, Wadhwa, Buss); Departments of Psychiatry and Human Behavior (Entringer, Wadhwa), Obstetrics and Gynecology (Wadhwa), and Epidemiology (Wadhwa), University of California, Irvine, School of Medicine, Orange; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku (Korja, H. Karlsson, L. Karlsson); Centre for Population Health Research, University of Turku and Turku University Hospital (Korja, H. Karlsson, L. Karlsson); Department of Paediatrics and Adolescent Medicine (L. Karlsson) and Department of Psychiatry (H. Karlsson), Department of Clinical Medicine, Turku University Hospital and University of Turku; Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill (Gilmore); Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill (Styner).
Saara NolviDepartment of Behavioral Neuroscience (Marr, Graham, Sturgeon, Schifsky, Fair) and Department of Psychiatry (Graham, Fair), Oregon Health and Science University School of Medicine, Portland; Department of Psychiatry, Massachusetts General Hospital, Boston (Marr); Department of Psychiatry, McLean Hospital, Belmont, Mass. (Marr); Masonic Institute for the Developing Brain, Institute of Child Development (Fair), and Department of Pediatrics (Feczko, Fair), University of Minnesota, Minneapolis; Department of Psychology and Speech-Language Pathology, University of Turku, Turku, Finland (Nolvi, Korja); Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin (Nolvi, Entringer, Buss); Department of Neuroscience, Earlham College, Richmond, Ind. (Thomas); Development, Health, and Disease Research Program and Departments of Pediatrics, Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Irvine (Rasmussen, Entringer, Wadhwa, Buss); Department of Pediatrics, University of California, Irvine, School of Medicine, Orange (Rasmussen, Entringer, Wadhwa, Buss); Departments of Psychiatry and Human Behavior (Entringer, Wadhwa), Obstetrics and Gynecology (Wadhwa), and Epidemiology (Wadhwa), University of California, Irvine, School of Medicine, Orange; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku (Korja, H. Karlsson, L. Karlsson); Centre for Population Health Research, University of Turku and Turku University Hospital (Korja, H. Karlsson, L. Karlsson); Department of Paediatrics and Adolescent Medicine (L. Karlsson) and Department of Psychiatry (H. Karlsson), Department of Clinical Medicine, Turku University Hospital and University of Turku; Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill (Gilmore); Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill (Styner).
Elina ThomasDepartment of Behavioral Neuroscience (Marr, Graham, Sturgeon, Schifsky, Fair) and Department of Psychiatry (Graham, Fair), Oregon Health and Science University School of Medicine, Portland; Department of Psychiatry, Massachusetts General Hospital, Boston (Marr); Department of Psychiatry, McLean Hospital, Belmont, Mass. (Marr); Masonic Institute for the Developing Brain, Institute of Child Development (Fair), and Department of Pediatrics (Feczko, Fair), University of Minnesota, Minneapolis; Department of Psychology and Speech-Language Pathology, University of Turku, Turku, Finland (Nolvi, Korja); Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin (Nolvi, Entringer, Buss); Department of Neuroscience, Earlham College, Richmond, Ind. (Thomas); Development, Health, and Disease Research Program and Departments of Pediatrics, Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Irvine (Rasmussen, Entringer, Wadhwa, Buss); Department of Pediatrics, University of California, Irvine, School of Medicine, Orange (Rasmussen, Entringer, Wadhwa, Buss); Departments of Psychiatry and Human Behavior (Entringer, Wadhwa), Obstetrics and Gynecology (Wadhwa), and Epidemiology (Wadhwa), University of California, Irvine, School of Medicine, Orange; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku (Korja, H. Karlsson, L. Karlsson); Centre for Population Health Research, University of Turku and Turku University Hospital (Korja, H. Karlsson, L. Karlsson); Department of Paediatrics and Adolescent Medicine (L. Karlsson) and Department of Psychiatry (H. Karlsson), Department of Clinical Medicine, Turku University Hospital and University of Turku; Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill (Gilmore); Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill (Styner).
Darrick SturgeonDepartment of Behavioral Neuroscience (Marr, Graham, Sturgeon, Schifsky, Fair) and Department of Psychiatry (Graham, Fair), Oregon Health and Science University School of Medicine, Portland; Department of Psychiatry, Massachusetts General Hospital, Boston (Marr); Department of Psychiatry, McLean Hospital, Belmont, Mass. (Marr); Masonic Institute for the Developing Brain, Institute of Child Development (Fair), and Department of Pediatrics (Feczko, Fair), University of Minnesota, Minneapolis; Department of Psychology and Speech-Language Pathology, University of Turku, Turku, Finland (Nolvi, Korja); Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin (Nolvi, Entringer, Buss); Department of Neuroscience, Earlham College, Richmond, Ind. (Thomas); Development, Health, and Disease Research Program and Departments of Pediatrics, Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Irvine (Rasmussen, Entringer, Wadhwa, Buss); Department of Pediatrics, University of California, Irvine, School of Medicine, Orange (Rasmussen, Entringer, Wadhwa, Buss); Departments of Psychiatry and Human Behavior (Entringer, Wadhwa), Obstetrics and Gynecology (Wadhwa), and Epidemiology (Wadhwa), University of California, Irvine, School of Medicine, Orange; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku (Korja, H. Karlsson, L. Karlsson); Centre for Population Health Research, University of Turku and Turku University Hospital (Korja, H. Karlsson, L. Karlsson); Department of Paediatrics and Adolescent Medicine (L. Karlsson) and Department of Psychiatry (H. Karlsson), Department of Clinical Medicine, Turku University Hospital and University of Turku; Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill (Gilmore); Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill (Styner).
Emma SchifskyDepartment of Behavioral Neuroscience (Marr, Graham, Sturgeon, Schifsky, Fair) and Department of Psychiatry (Graham, Fair), Oregon Health and Science University School of Medicine, Portland; Department of Psychiatry, Massachusetts General Hospital, Boston (Marr); Department of Psychiatry, McLean Hospital, Belmont, Mass. (Marr); Masonic Institute for the Developing Brain, Institute of Child Development (Fair), and Department of Pediatrics (Feczko, Fair), University of Minnesota, Minneapolis; Department of Psychology and Speech-Language Pathology, University of Turku, Turku, Finland (Nolvi, Korja); Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin (Nolvi, Entringer, Buss); Department of Neuroscience, Earlham College, Richmond, Ind. (Thomas); Development, Health, and Disease Research Program and Departments of Pediatrics, Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Irvine (Rasmussen, Entringer, Wadhwa, Buss); Department of Pediatrics, University of California, Irvine, School of Medicine, Orange (Rasmussen, Entringer, Wadhwa, Buss); Departments of Psychiatry and Human Behavior (Entringer, Wadhwa), Obstetrics and Gynecology (Wadhwa), and Epidemiology (Wadhwa), University of California, Irvine, School of Medicine, Orange; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku (Korja, H. Karlsson, L. Karlsson); Centre for Population Health Research, University of Turku and Turku University Hospital (Korja, H. Karlsson, L. Karlsson); Department of Paediatrics and Adolescent Medicine (L. Karlsson) and Department of Psychiatry (H. Karlsson), Department of Clinical Medicine, Turku University Hospital and University of Turku; Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill (Gilmore); Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill (Styner).
Jerod M RasmussenDepartment of Behavioral Neuroscience (Marr, Graham, Sturgeon, Schifsky, Fair) and Department of Psychiatry (Graham, Fair), Oregon Health and Science University School of Medicine, Portland; Department of Psychiatry, Massachusetts General Hospital, Boston (Marr); Department of Psychiatry, McLean Hospital, Belmont, Mass. (Marr); Masonic Institute for the Developing Brain, Institute of Child Development (Fair), and Department of Pediatrics (Feczko, Fair), University of Minnesota, Minneapolis; Department of Psychology and Speech-Language Pathology, University of Turku, Turku, Finland (Nolvi, Korja); Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin (Nolvi, Entringer, Buss); Department of Neuroscience, Earlham College, Richmond, Ind. (Thomas); Development, Health, and Disease Research Program and Departments of Pediatrics, Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Irvine (Rasmussen, Entringer, Wadhwa, Buss); Department of Pediatrics, University of California, Irvine, School of Medicine, Orange (Rasmussen, Entringer, Wadhwa, Buss); Departments of Psychiatry and Human Behavior (Entringer, Wadhwa), Obstetrics and Gynecology (Wadhwa), and Epidemiology (Wadhwa), University of California, Irvine, School of Medicine, Orange; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku (Korja, H. Karlsson, L. Karlsson); Centre for Population Health Research, University of Turku and Turku University Hospital (Korja, H. Karlsson, L. Karlsson); Department of Paediatrics and Adolescent Medicine (L. Karlsson) and Department of Psychiatry (H. Karlsson), Department of Clinical Medicine, Turku University Hospital and University of Turku; Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill (Gilmore); Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill (Styner).
John H GilmoreDepartment of Behavioral Neuroscience (Marr, Graham, Sturgeon, Schifsky, Fair) and Department of Psychiatry (Graham, Fair), Oregon Health and Science University School of Medicine, Portland; Department of Psychiatry, Massachusetts General Hospital, Boston (Marr); Department of Psychiatry, McLean Hospital, Belmont, Mass. (Marr); Masonic Institute for the Developing Brain, Institute of Child Development (Fair), and Department of Pediatrics (Feczko, Fair), University of Minnesota, Minneapolis; Department of Psychology and Speech-Language Pathology, University of Turku, Turku, Finland (Nolvi, Korja); Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin (Nolvi, Entringer, Buss); Department of Neuroscience, Earlham College, Richmond, Ind. (Thomas); Development, Health, and Disease Research Program and Departments of Pediatrics, Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Irvine (Rasmussen, Entringer, Wadhwa, Buss); Department of Pediatrics, University of California, Irvine, School of Medicine, Orange (Rasmussen, Entringer, Wadhwa, Buss); Departments of Psychiatry and Human Behavior (Entringer, Wadhwa), Obstetrics and Gynecology (Wadhwa), and Epidemiology (Wadhwa), University of California, Irvine, School of Medicine, Orange; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku (Korja, H. Karlsson, L. Karlsson); Centre for Population Health Research, University of Turku and Turku University Hospital (Korja, H. Karlsson, L. Karlsson); Department of Paediatrics and Adolescent Medicine (L. Karlsson) and Department of Psychiatry (H. Karlsson), Department of Clinical Medicine, Turku University Hospital and University of Turku; Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill (Gilmore); Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill (Styner).
Martin StynerDepartment of Behavioral Neuroscience (Marr, Graham, Sturgeon, Schifsky, Fair) and Department of Psychiatry (Graham, Fair), Oregon Health and Science University School of Medicine, Portland; Department of Psychiatry, Massachusetts General Hospital, Boston (Marr); Department of Psychiatry, McLean Hospital, Belmont, Mass. (Marr); Masonic Institute for the Developing Brain, Institute of Child Development (Fair), and Department of Pediatrics (Feczko, Fair), University of Minnesota, Minneapolis; Department of Psychology and Speech-Language Pathology, University of Turku, Turku, Finland (Nolvi, Korja); Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin (Nolvi, Entringer, Buss); Department of Neuroscience, Earlham College, Richmond, Ind. (Thomas); Development, Health, and Disease Research Program and Departments of Pediatrics, Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Irvine (Rasmussen, Entringer, Wadhwa, Buss); Department of Pediatrics, University of California, Irvine, School of Medicine, Orange (Rasmussen, Entringer, Wadhwa, Buss); Departments of Psychiatry and Human Behavior (Entringer, Wadhwa), Obstetrics and Gynecology (Wadhwa), and Epidemiology (Wadhwa), University of California, Irvine, School of Medicine, Orange; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku (Korja, H. Karlsson, L. Karlsson); Centre for Population Health Research, University of Turku and Turku University Hospital (Korja, H. Karlsson, L. Karlsson); Department of Paediatrics and Adolescent Medicine (L. Karlsson) and Department of Psychiatry (H. Karlsson), Department of Clinical Medicine, Turku University Hospital and University of Turku; Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill (Gilmore); Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill (Styner).
Sonja EntringerDepartment of Behavioral Neuroscience (Marr, Graham, Sturgeon, Schifsky, Fair) and Department of Psychiatry (Graham, Fair), Oregon Health and Science University School of Medicine, Portland; Department of Psychiatry, Massachusetts General Hospital, Boston (Marr); Department of Psychiatry, McLean Hospital, Belmont, Mass. (Marr); Masonic Institute for the Developing Brain, Institute of Child Development (Fair), and Department of Pediatrics (Feczko, Fair), University of Minnesota, Minneapolis; Department of Psychology and Speech-Language Pathology, University of Turku, Turku, Finland (Nolvi, Korja); Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin (Nolvi, Entringer, Buss); Department of Neuroscience, Earlham College, Richmond, Ind. (Thomas); Development, Health, and Disease Research Program and Departments of Pediatrics, Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Irvine (Rasmussen, Entringer, Wadhwa, Buss); Department of Pediatrics, University of California, Irvine, School of Medicine, Orange (Rasmussen, Entringer, Wadhwa, Buss); Departments of Psychiatry and Human Behavior (Entringer, Wadhwa), Obstetrics and Gynecology (Wadhwa), and Epidemiology (Wadhwa), University of California, Irvine, School of Medicine, Orange; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku (Korja, H. Karlsson, L. Karlsson); Centre for Population Health Research, University of Turku and Turku University Hospital (Korja, H. Karlsson, L. Karlsson); Department of Paediatrics and Adolescent Medicine (L. Karlsson) and Department of Psychiatry (H. Karlsson), Department of Clinical Medicine, Turku University Hospital and University of Turku; Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill (Gilmore); Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill (Styner).
Pathik D WadhwaDepartment of Behavioral Neuroscience (Marr, Graham, Sturgeon, Schifsky, Fair) and Department of Psychiatry (Graham, Fair), Oregon Health and Science University School of Medicine, Portland; Department of Psychiatry, Massachusetts General Hospital, Boston (Marr); Department of Psychiatry, McLean Hospital, Belmont, Mass. (Marr); Masonic Institute for the Developing Brain, Institute of Child Development (Fair), and Department of Pediatrics (Feczko, Fair), University of Minnesota, Minneapolis; Department of Psychology and Speech-Language Pathology, University of Turku, Turku, Finland (Nolvi, Korja); Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin (Nolvi, Entringer, Buss); Department of Neuroscience, Earlham College, Richmond, Ind. (Thomas); Development, Health, and Disease Research Program and Departments of Pediatrics, Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Irvine (Rasmussen, Entringer, Wadhwa, Buss); Department of Pediatrics, University of California, Irvine, School of Medicine, Orange (Rasmussen, Entringer, Wadhwa, Buss); Departments of Psychiatry and Human Behavior (Entringer, Wadhwa), Obstetrics and Gynecology (Wadhwa), and Epidemiology (Wadhwa), University of California, Irvine, School of Medicine, Orange; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku (Korja, H. Karlsson, L. Karlsson); Centre for Population Health Research, University of Turku and Turku University Hospital (Korja, H. Karlsson, L. Karlsson); Department of Paediatrics and Adolescent Medicine (L. Karlsson) and Department of Psychiatry (H. Karlsson), Department of Clinical Medicine, Turku University Hospital and University of Turku; Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill (Gilmore); Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill (Styner).
Riikka KorjaDepartment of Behavioral Neuroscience (Marr, Graham, Sturgeon, Schifsky, Fair) and Department of Psychiatry (Graham, Fair), Oregon Health and Science University School of Medicine, Portland; Department of Psychiatry, Massachusetts General Hospital, Boston (Marr); Department of Psychiatry, McLean Hospital, Belmont, Mass. (Marr); Masonic Institute for the Developing Brain, Institute of Child Development (Fair), and Department of Pediatrics (Feczko, Fair), University of Minnesota, Minneapolis; Department of Psychology and Speech-Language Pathology, University of Turku, Turku, Finland (Nolvi, Korja); Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin (Nolvi, Entringer, Buss); Department of Neuroscience, Earlham College, Richmond, Ind. (Thomas); Development, Health, and Disease Research Program and Departments of Pediatrics, Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Irvine (Rasmussen, Entringer, Wadhwa, Buss); Department of Pediatrics, University of California, Irvine, School of Medicine, Orange (Rasmussen, Entringer, Wadhwa, Buss); Departments of Psychiatry and Human Behavior (Entringer, Wadhwa), Obstetrics and Gynecology (Wadhwa), and Epidemiology (Wadhwa), University of California, Irvine, School of Medicine, Orange; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku (Korja, H. Karlsson, L. Karlsson); Centre for Population Health Research, University of Turku and Turku University Hospital (Korja, H. Karlsson, L. Karlsson); Department of Paediatrics and Adolescent Medicine (L. Karlsson) and Department of Psychiatry (H. Karlsson), Department of Clinical Medicine, Turku University Hospital and University of Turku; Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill (Gilmore); Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill (Styner).
Hasse KarlssonDepartment of Behavioral Neuroscience (Marr, Graham, Sturgeon, Schifsky, Fair) and Department of Psychiatry (Graham, Fair), Oregon Health and Science University School of Medicine, Portland; Department of Psychiatry, Massachusetts General Hospital, Boston (Marr); Department of Psychiatry, McLean Hospital, Belmont, Mass. (Marr); Masonic Institute for the Developing Brain, Institute of Child Development (Fair), and Department of Pediatrics (Feczko, Fair), University of Minnesota, Minneapolis; Department of Psychology and Speech-Language Pathology, University of Turku, Turku, Finland (Nolvi, Korja); Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin (Nolvi, Entringer, Buss); Department of Neuroscience, Earlham College, Richmond, Ind. (Thomas); Development, Health, and Disease Research Program and Departments of Pediatrics, Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Irvine (Rasmussen, Entringer, Wadhwa, Buss); Department of Pediatrics, University of California, Irvine, School of Medicine, Orange (Rasmussen, Entringer, Wadhwa, Buss); Departments of Psychiatry and Human Behavior (Entringer, Wadhwa), Obstetrics and Gynecology (Wadhwa), and Epidemiology (Wadhwa), University of California, Irvine, School of Medicine, Orange; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku (Korja, H. Karlsson, L. Karlsson); Centre for Population Health Research, University of Turku and Turku University Hospital (Korja, H. Karlsson, L. Karlsson); Department of Paediatrics and Adolescent Medicine (L. Karlsson) and Department of Psychiatry (H. Karlsson), Department of Clinical Medicine, Turku University Hospital and University of Turku; Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill (Gilmore); Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill (Styner).
Linnea KarlssonDepartment of Behavioral Neuroscience (Marr, Graham, Sturgeon, Schifsky, Fair) and Department of Psychiatry (Graham, Fair), Oregon Health and Science University School of Medicine, Portland; Department of Psychiatry, Massachusetts General Hospital, Boston (Marr); Department of Psychiatry, McLean Hospital, Belmont, Mass. (Marr); Masonic Institute for the Developing Brain, Institute of Child Development (Fair), and Department of Pediatrics (Feczko, Fair), University of Minnesota, Minneapolis; Department of Psychology and Speech-Language Pathology, University of Turku, Turku, Finland (Nolvi, Korja); Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin (Nolvi, Entringer, Buss); Department of Neuroscience, Earlham College, Richmond, Ind. (Thomas); Development, Health, and Disease Research Program and Departments of Pediatrics, Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Irvine (Rasmussen, Entringer, Wadhwa, Buss); Department of Pediatrics, University of California, Irvine, School of Medicine, Orange (Rasmussen, Entringer, Wadhwa, Buss); Departments of Psychiatry and Human Behavior (Entringer, Wadhwa), Obstetrics and Gynecology (Wadhwa), and Epidemiology (Wadhwa), University of California, Irvine, School of Medicine, Orange; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku (Korja, H. Karlsson, L. Karlsson); Centre for Population Health Research, University of Turku and Turku University Hospital (Korja, H. Karlsson, L. Karlsson); Department of Paediatrics and Adolescent Medicine (L. Karlsson) and Department of Psychiatry (H. Karlsson), Department of Clinical Medicine, Turku University Hospital and University of Turku; Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill (Gilmore); Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill (Styner).
Claudia BussDepartment of Behavioral Neuroscience (Marr, Graham, Sturgeon, Schifsky, Fair) and Department of Psychiatry (Graham, Fair), Oregon Health and Science University School of Medicine, Portland; Department of Psychiatry, Massachusetts General Hospital, Boston (Marr); Department of Psychiatry, McLean Hospital, Belmont, Mass. (Marr); Masonic Institute for the Developing Brain, Institute of Child Development (Fair), and Department of Pediatrics (Feczko, Fair), University of Minnesota, Minneapolis; Department of Psychology and Speech-Language Pathology, University of Turku, Turku, Finland (Nolvi, Korja); Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin (Nolvi, Entringer, Buss); Department of Neuroscience, Earlham College, Richmond, Ind. (Thomas); Development, Health, and Disease Research Program and Departments of Pediatrics, Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Irvine (Rasmussen, Entringer, Wadhwa, Buss); Department of Pediatrics, University of California, Irvine, School of Medicine, Orange (Rasmussen, Entringer, Wadhwa, Buss); Departments of Psychiatry and Human Behavior (Entringer, Wadhwa), Obstetrics and Gynecology (Wadhwa), and Epidemiology (Wadhwa), University of California, Irvine, School of Medicine, Orange; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku (Korja, H. Karlsson, L. Karlsson); Centre for Population Health Research, University of Turku and Turku University Hospital (Korja, H. Karlsson, L. Karlsson); Department of Paediatrics and Adolescent Medicine (L. Karlsson) and Department of Psychiatry (H. Karlsson), Department of Clinical Medicine, Turku University Hospital and University of Turku; Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill (Gilmore); Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill (Styner).
Damien A FairDepartment of Behavioral Neuroscience (Marr, Graham, Sturgeon, Schifsky, Fair) and Department of Psychiatry (Graham, Fair), Oregon Health and Science University School of Medicine, Portland; Department of Psychiatry, Massachusetts General Hospital, Boston (Marr); Department of Psychiatry, McLean Hospital, Belmont, Mass. (Marr); Masonic Institute for the Developing Brain, Institute of Child Development (Fair), and Department of Pediatrics (Feczko, Fair), University of Minnesota, Minneapolis; Department of Psychology and Speech-Language Pathology, University of Turku, Turku, Finland (Nolvi, Korja); Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin (Nolvi, Entringer, Buss); Department of Neuroscience, Earlham College, Richmond, Ind. (Thomas); Development, Health, and Disease Research Program and Departments of Pediatrics, Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Irvine (Rasmussen, Entringer, Wadhwa, Buss); Department of Pediatrics, University of California, Irvine, School of Medicine, Orange (Rasmussen, Entringer, Wadhwa, Buss); Departments of Psychiatry and Human Behavior (Entringer, Wadhwa), Obstetrics and Gynecology (Wadhwa), and Epidemiology (Wadhwa), University of California, Irvine, School of Medicine, Orange; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku (Korja, H. Karlsson, L. Karlsson); Centre for Population Health Research, University of Turku and Turku University Hospital (Korja, H. Karlsson, L. Karlsson); Department of Paediatrics and Adolescent Medicine (L. Karlsson) and Department of Psychiatry (H. Karlsson), Department of Clinical Medicine, Turku University Hospital and University of Turku; Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill (Gilmore); Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill (Styner).
McLean Hospital · US
Funding
TRAINING PROGRAM IN HEALTH INFORMATICST15LM007088 · NLM · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAM R HERSH, Vishnu Mohan · 1992 to 2026
$23.4MIdentification of outcome-based sub-populations using deep phenotyping and precision functional mapping across ADHD and ASDR01MH096773 · NIMH · UNIVERSITY OF MINNESOTA · PI DOSENBACH, NICO, FAIR, DAMIEN A · 2012 to 2024
$9.4MOregon Clinical and Translational Research Institute TL1 ProgramTL1TR002371 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ALLISON Deborah FRYER, JESSINA C MCGREGOR · 2017 to 2026
$6.2MEMA Assessment of Biobehavioral Processes in Human PregnancyR01HD060628 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WADHWA, PATHIK D · 2010 to 2014
$3.4MFETAL PROGRAMMING OF THE NEWBORN AND INFANT HUMAN BRAINR01MH091351 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BUSS, CLAUDIA, WADHWA, PATHIK D · 2011 to 2015
$3.3MLINKS BETWEEN MATERNAL PSYCHOLOGICAL STRESS AND INFLAMMATION DURING PREGNANCY AND POTENTIAL FOR PREVENTIVE INTERVENTION: Supplement to R00MH111805R00MH111805 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI GRAHAM, ALICE M · 2018 to 2020
$934kFetal Programming of Human Newborn Energy Homeostasis Brain NetworksR00HD100593 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI RASMUSSEN, JEROD MICHAEL · 2023 to 2025
$744kFunctional Circuits as an Endophenotype for ADHD in ChildrenR00MH091238 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI FAIR, DAMIEN A · 2011 to 2013
$723kMaternal psychological stress during pregnancy as a key mechanism for the intergenerational transmission of childhood traumatic stressF30MH118762 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI MARR, MOLLIE CHRISTINE · 2018 to 2022
$246kNCATS NIH HHS TL1 TR002371NICHD NIH HHS R00 HD100593NICHD NIH HHS R01 HD060628NIMH NIH HHS F30 MH118762NIMH NIH HHS R00 MH091238NIMH NIH HHS R00 MH111805NIMH NIH HHS R01 MH091351NIMH NIH HHS R01 MH096773NLM NIH HHS T15 LM007088
Abstract
objectiveMaternal psychological stress during pregnancy is a common risk factor for psychiatric disorders in offspring, but little is known about how heterogeneity of stress trajectories during pregnancy affect brain systems and behavioral phenotypes in infancy. This study was designed to address this gap in knowledge.
methodsMaternal anxiety, stress, and depression were assessed at multiple time points during pregnancy in two independent low-risk mother-infant cohorts (N=115 and N=2,156). Trajectories in maternal stress levels in relation to infant negative affect were examined in both cohorts. Neonatal amygdala resting-state functional connectivity MRI was examined in a subset of one cohort (N=60) to explore the potential relationship between maternal stress trajectories and brain systems in infants relevant to negative affect.
resultsFour distinct trajectory clusters, characterized by changing patterns of stress over time, and two magnitude clusters, characterized by severity of stress, were identified in the original mother-infant cohort (N=115). The magnitude clusters were not associated with infant outcomes. The trajectory characterized by increasing stress in late pregnancy was associated with blunted development of infant negative affect. This relationship was replicated in the second, larger cohort (N=2,156). In addition, the trajectories that included increasing or peak maternal stress in late pregnancy were related to stronger neonatal amygdala functional connectivity to the anterior insula and the ventromedial prefrontal cortex in the exploratory analysis.
conclusionsThe trajectory of maternal stress appears to be important for offspring brain and behavioral development. Understanding heterogeneity in trajectories of maternal stress and their influence on infant brain and behavioral development is critical to developing targeted interventions.
Indexed as
AmygdalaPrefrontal CortexAffectFemaleHumansInfantInfant, NewbornMagnetic Resonance ImagingMothersPregnancyDevelopmentEmotionFunctional Random ForestNeuroimagingPre/Peri/Postnatal IssuesStress
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.