ArticleJournal of cachexia, sarcopenia and muscle2023
Assessment of the bidirectional causal association between frailty and depression: A Mendelian randomization study.
Article in Journal of cachexia, sarcopenia and muscle, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effectiveness of nudge-based physical activity interventions in frail older adults: a systematic review.The international journal of behavioral nutrition and physical activity · 2026Pooled it
- Handgrip strength and relationship with non-motor symptoms in Parkinson's disease.Journal of Parkinson's disease · 2026Article
- Mapping the genetically predicted associations between lower-extremity muscle traits and spinal diseases.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Interacting and joint effects of frailty and depressive symptoms in relation to risk of cardio-oncology comorbidity in older adults from three prospective cohorts.BMC geriatrics · 2026Article
- Frailty Syndrome and Depressive Symptoms in Patients with Ischemic Heart Disease.Diagnostics (Basel, Switzerland) · 2026Article
- PolyGenie: a reproducible Nextflow pipeline for phenome-wide association studies using polygenic risk scores.NAR genomics and bioinformatics · 2026Article
- Genetic mechanisms, brain structures, and peripheral biomarkers mediate the relationship between physical frailty and neuropsychiatric disorders.Journal of advanced research · 2026Article
- Association between frailty status and depression among older adults: panel data analysis of three longitudinal cohort studies.BMC public health · 2026Article
- Depressive symptoms affect frailty through attitudes to aging: a cross-lagged analysis.BMC geriatrics · 2025Article
- Assessment of relationships between frailty and diabetes: A two-sample Mendelian randomization study.The Journal of international medical research · 2025Article
- Identification of novel biomarkers and drug targets for frailty-related skeletal muscle aging: a multi-omics study.QJM : monthly journal of the Association of Physicians · 2025Article
- Habitual sweet and bitter beverage consumption in relation to the risk of frailty and sarcopenia-related traits: a Mendelian randomization study.BMC geriatrics · 2025Article
- Network relationships among depressive symptoms, sleep quality, and frailty in Chinese older adults: an undirected and bayesian network analysis.BMC geriatrics · 2025Article
- Identifying modifiable factors and their joint effect on frailty: a large population-based prospective cohort study.GeroScience · 2025Article
- Rheumatoid Arthritis and Tuberculosis.International journal of rheumatic diseases · 2025Article
- Causal association of sarcopenia-related traits with brain cortical structure: a bidirectional Mendelian randomization study.Aging clinical and experimental research · 2025Article
- The association between PMBMC public health · 2024Article
- Causal relationship between genetically predicted mental disorders and frailty: a bidirectional and multivariable mendelian randomization study.BMC psychiatry · 2024Article
- Causal associations between frailty and low back pain: a bidirectional two-sample mendelian randomization study.Aging clinical and experimental research · 2024Article
- Predictive role of depressive symptoms on frailty and its components in Chinese middle-aged and older adults: a longitudinal analysis.BMC public health · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObservational studies have demonstrated a strong bidirectional association between frailty and depression, but it remains unclear whether this association reflects causality. This study aimed to examine the bidirectional causal relationship between frailty and depression.
methodsUsing genome-wide association study summary data, two-sample Mendelian randomization was performed to test for the potential bidirectional causality between frailty, as defined by both the frailty index and the frailty phenotype, and depression. Several frailty-related traits were additionally investigated, including weaker hand grip strength, slower walking pace and physical inactivity. Findings were replicated using an independent depression data source and verified using multiple sensitivity analyses.
resultsGenetically predicted higher frailty index (odds ratio [OR], 1.86; P < 0.001), higher frailty phenotype score (OR, 2.79; P < 0.001), lower grip strength (OR, 1.23; P = 0.003), slower walking pace (OR, 1.55; P = 0.027) and physical inactivity (OR, 1.44; P = 0.003) all were associated with a higher risk of depression. As for the reverse direction, genetic liability to depression showed consistent associations with a higher frailty index (beta, 0.167; P < 0.001) and a higher frailty phenotype score (beta, 0.067; P = 0.001), but not with other frailty-related traits that were investigated. The results were stable across sensitivity analyses and across depression datasets.
conclusionsOur findings add novel evidence supporting the bidirectional causal association between frailty and depression. Improving balance and muscle strength and increasing physical activity may be beneficial in both depression and frailty.
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