ArticleBMC pediatrics2023
Comparing presentations and outcomes of children with cancer: a study between a lower-middle-income country and a high-income country.
Article in BMC pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Clinical presentation of bone tumours in children and young people: a systematic review and meta-analysis.Archives of disease in childhood · 2025Pooled it
- Physical late effects of treatment among survivors of childhood cancer in low- and middle-income countries: a systematic review.Journal of cancer survivorship : research and practice · 2025Pooled it
- Pooled it
- Factors associated with level of knowledge on childhood cancer early warning signs among intern doctors in Tanzania.BMC medical education · 2026Article
- Pediatric Lymphoma in Jordan: A Retrospective Single-Center Study of Clinical Presentation, Treatment, and Outcomes.Cureus · 2026Article
- The Diagnostic Evolution of Haematological Neoplasms: A Narrative Review of the Road to Two Genetically Focused Classification Systems Through a Resource-Limited Perspective.Diagnostics (Basel, Switzerland) · 2026Review
- Childhood cancer care in Northern Tanzania: hospital infrastructure and provision of services.Frontiers in pediatrics · 2026Article
- Transforming pediatric intensive care unit outcomes in pediatric hematology-oncology and hematopoietic stem cell transplantation through golden hour care in a low- and middle-income country: a 10-year analysis.Critical care science · 2026Article
- Article
- Prospective Psychometric Validation of the Swahili Translated and Adapted Pediatric Patient Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (Ped-PRO-CTCAE).Measurement and evaluations in cancer care · 2025Article
- Radiotherapy Utilization and Treatment Continuity of Pediatric Patients With Brain Tumor in Egypt: A Decade of Data.JCO global oncology · 2025Article
- Childhood cancer survival in low- and middle-income countries and the Global South: emerging evidence and critical gaps from a scoping review of observational studies.EJC paediatric oncology · 2025Review
- Disparities in pediatric oncology access and outcomes in the occupied Palestinian territories: a retrospective study from Augusta Victoria Hospital.EClinicalMedicine · 2025Article
- Understanding the influence of social determinants of health on symptom reporting in pediatric cancer.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2025Article
- Knowledge, attitudes, and practices of healthcare providers toward ADR reporting regarding thiopurine drugs for the treatment of acute lymphoblastic leukemia at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.Frontiers in pharmacology · 2025Article
- Retrospective analysis of the efficacy and safety of anlotinib plus sintilimab (anti-PD-1) as maintenance therapy in advanced pediatric solid tumors.Frontiers in oncology · 2025Article
- Inter-Ethnic Variations in the Clinical, Pathological, and Molecular Characteristics of Wilms Tumor.Cancers · 2024Review
- Pediatric cancer mortality: Analyzing early deaths and fatalities in a resource-limited tertiary care context.PloS one · 2024Article
- Prevalence of Undernutrition Among Children and Adolescents with Cancer Living in Sub-Saharan African Countries: A Systematic Review and Meta-analysis.Global pediatric health · 2024Review
- Evaluation of diagnostic interval in children with newly diagnosed paediatric cancers: A Cross-sectional study.Medical journal, Armed Forces IndiaArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSubstantial progress has been achieved in managing childhood cancers in many high-income countries (HICs). In contrast, survival rates in lower-middle-income countries (LMICs) are less favorable. Here, we aimed to compare outcomes and associated factors between two large institutions; Egypt (LMIC) and Germany (HIC).
methodsA retrospective review was conducted on newly diagnosed children with cancer between 2006 and 2010 in the departments of pediatric oncology at the South Egypt Cancer Institute (SECI) (n = 502) and the University Hospital of Cologne-Uniklinik Köln (UKK) (n = 238). Characteristics including age, sex, diagnosis, travel time from home to the cancer center, the time interval from initial symptoms to the start of treatment, treatment-related complications, compliance, and outcome were analyzed. A Cox proportional hazards regression model was applied to investigate the influence of risk factors.
resultsThe most common diagnoses in SECI were leukemia (48.8%), lymphomas (24.1%), brain tumors (1%), and other solid tumors (24.7%), compared to 22.3%, 19.3%, 28.6%, and 26.5% in UKK, respectively. Patients from SECI were younger (5.2 vs. 9.0 years, P < 0.001), needed longer travel time to reach the treatment center (1.44 ± 0.07 vs. 0.53 ± 0.03 h, P < 0.001), received therapy earlier (7.53 ± 0.59 vs. 12.09 ± 1.01 days, P = 0.034), showed less compliance (85.1% vs. 97.1%, P < 0.001), and relapsed earlier (7 vs. 12 months, P = 0.008). Deaths in SECI were more frequent (47.4% vs. 18.1%) and caused mainly by infection (60% in SECI, 7% in UKK), while in UKK, they were primarily disease-related (79% in UKK, 27.7% in SECI). Differences in overall and event-free survival were observed for leukemias but not for non-Hodgkin lymphoma.
conclusionsOutcome differences were associated with different causes of death and other less prominent factors.
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