Evidence map›Paper›PMID 37670025›Full record

ArticleScientific reports2023

Co-administration of an effector antibody enhances the half-life and therapeutic potential of RNA-encoded nanobodies.

Moritz Thran, Marion Pönisch, Hillary Danz, Nigel Horscroft, Konstantin Ichtchenko, Saul Tzipori, Charles B Shoemaker

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Monoclonal Antibodies Targeting Bacterial Infections: A Broad Review of the Field.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  2. Review
  3. Review
  4. In vivo mRNA expression of a multi-mechanistic mAb combination protects against Staphylococcus aureus infection.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  5. Review
  6. The state of play of rodent models for the study ofJournal of medical microbiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Moritz ThranCureVac SE, 72076, Tübingen, Germany.
Marion PönischCureVac SE, 72076, Tübingen, Germany.
Hillary DanzDepartment of Infectious Disease and Global Health, Tufts Cummings School of Veterinary Medicine, North Grafton, MA, 01536, USA.
Nigel HorscroftCureVac SE, 72076, Tübingen, Germany.
Konstantin IchtchenkoDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, 10016, USA.
Saul TziporiDepartment of Infectious Disease and Global Health, Tufts Cummings School of Veterinary Medicine, North Grafton, MA, 01536, USA.
Charles B ShoemakerDepartment of Infectious Disease and Global Health, Tufts Cummings School of Veterinary Medicine, North Grafton, MA, 01536, USA. charles.shoemaker@tufts.edu.
CureVac (Germany) · DENew England Disabled Sports · USNew York University · USTufts University · US

Funding

Novel therapeutic approaches to treatment of botulinum neurotoxin poisoning.R01AI093504 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Konstantin Ichtchenko · 2011 to 2026
$13.9M
Novel therapeutic approaches to treatment of botulinum neurotoxin poisoning.U01AI093504 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ICHTCHENKO, KONSTANTIN · 2019 to 2021
$3.4M
Molecular mechanisms of botulinum neurotoxin neutralizationR01AI125704 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI JIN, RONGSHENG, SHOEMAKER, CHARLES BIX · 2016 to 2020
$3.0M
NIAID NIH HHS R01 AI093504NIAID NIH HHS R01 AI125704NIAID NIH HHS U01 AI093504
6 · The paper itself

Abstract

The incidence of Clostridioides difficile infection (CDI) and associated mortality have increased rapidly worldwide in recent years. Therefore, it is critical to develop new therapies for CDI. Here we report on the development of mRNA-LNPs encoding camelid-derived V

Indexed as

Clostridioides difficileSingle-Domain AntibodiesAnimalsAntibodiesHalf-LifeMiceRNARNA, MessengerSwineAntibodiesRNARNA, MessengerSingle-Domain Antibodies

Identifiers

PMID37670025
PMCPMC10480410
OpenAlexW4386440712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.