SynthesisNature communications2023
Demonstrating paths for unlocking the value of cloud genomics through cross cohort analysis.
Synthesis in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Whole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals.Genome biology · 2025Pooled it
- Enabling secure discovery in trusted research environments with improved tooling.Nature medicine · 2026Article
- Characterizing core outcomes of responsible stewardship for human genomic data in the cloud.BMC medical genomics · 2026Article
- Large-scale manual curation and harmonization of metadata from metagenomic and cancer genomic repositories: challenges and solutions.Database : the journal of biological databases and curation · 2026Article
- Genetic and Genomic Testing in Cardiovascular Disease: A Policy Statement From the American Heart Association.Circulation · 2025Review
- Large-scale Manual Curation and Harmonization of Metadata from Metagenomic and Cancer Genomic Repositories: Challenges and Solutions.bioRxiv : the preprint server for biology · 2025Article
- Realizing the full potential of Our Future Health through data linkage and trans-biobank efforts.Nature genetics · 2025Article
- A one-shot, lossless algorithm for cross-cohort learning in mixed-outcomes analysis.Patterns (New York, N.Y.) · 2025Article
- Optimizing UK biobank cloud-based research analysis platform to fine-map coronary artery disease loci in whole genome sequencing data.Scientific reports · 2025Article
- Biobanking with genetics shapes precision medicine and global health.Nature reviews. Genetics · 2025Review
- The Federated European Genome-Phenome Archive as a global network for sharing human genomics data.Nature genetics · 2025Article
- A Comprehensive Review of the Genetics of Dyslipidemias and Risk of Atherosclerotic Cardiovascular Disease.Nutrients · 2025Review
- A call to action to scale up research and clinical genomic data sharing.Nature reviews. Genetics · 2025Review
- Scalable summary-statistics-based heritability estimation method with individual genotype level accuracy.Genome research · 2024Article
- A Clinician's Guide to Sharing Data for AI in Ophthalmology.Investigative ophthalmology & visual science · 2024Review
- Genomic data in the All of Us Research Program.Nature · 2024Article
- Future-proofing genomic data and consent management: a comprehensive review of technology innovations.GigaScience · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
Recently, large scale genomic projects such as All of Us and the UK Biobank have introduced a new research paradigm where data are stored centrally in cloud-based Trusted Research Environments (TREs). To characterize the advantages and drawbacks of different TRE attributes in facilitating cross-cohort analysis, we conduct a Genome-Wide Association Study of standard lipid measures using two approaches: meta-analysis and pooled analysis. Comparison of full summary data from both approaches with an external study shows strong correlation of known loci with lipid levels (R
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.