Evidence map›Paper›PMID 37669927›Full record

ArticleNature communications2023

Pathological pallidal beta activity in Parkinson's disease is sustained during sleep and associated with sleep disturbance.

Zixiao Yin, Ruoyu Ma, Qi An, Yichen Xu, Yifei Gan, Guanyu Zhu, Yin Jiang, Ning Zhang, Anchao Yang, Fangang Meng and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Zixiao YinDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID http://orcid.org/0000-0001-7088-8031
Ruoyu MaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID http://orcid.org/0000-0002-2334-6624
Qi AnDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yichen XuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yifei GanDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Guanyu ZhuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yin JiangDepartment of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Ning ZhangDepartment of Neuropsychiatry, Behavioral Neurology and Sleep Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Anchao YangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Fangang MengDepartment of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Andrea A KühnDepartment of Neurology, Movement Disorders and Neuromodulation Unit, Charité - Universitätsmedizin Berlin, Chariteplatz 1, 10117, Berlin, Germany.ORCID http://orcid.org/0000-0002-4134-9060
Hagai BergmanThe Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem, Israel.ORCID http://orcid.org/0000-0002-2402-6673
Wolf-Julian Neumann *Department of Neurology, Movement Disorders and Neuromodulation Unit, Charité - Universitätsmedizin Berlin, Chariteplatz 1, 10117, Berlin, Germany. julian.neumann@charite.de.ORCID http://orcid.org/0000-0002-6758-9708
Jianguo Zhang *Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. zjguo73@126.com.ORCID http://orcid.org/0000-0002-0009-0574
Capital Medical University · CNCharité - Universitätsmedizin Berlin · DEHebrew University of Jerusalem · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is associated with excessive beta activity in the basal ganglia. Brain sensing implants aim to leverage this biomarker for demand-dependent adaptive stimulation. Sleep disturbance is among the most common non-motor symptoms in PD, but its relationship with beta activity is unknown. To investigate the clinical potential of beta activity as a biomarker for sleep quality in PD, we recorded pallidal local field potentials during polysomnography in PD patients off dopaminergic medication and compared the results to dystonia patients. PD patients exhibited sustained and elevated beta activity across wakefulness, rapid eye movement (REM), and non-REM sleep, which was correlated with sleep disturbance. Simulation of adaptive stimulation revealed that sleep-related beta activity changes remain unaccounted for by current algorithms, with potential negative outcomes in sleep quality and overall quality of life for patients.

Indexed as

Parkinson DiseaseSleep Wake DisordersBasal GangliaGlobus PallidusHumansQuality of LifeSleep

Identifiers

PMID37669927
PMCPMC10480217
OpenAlexW4386462126

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.