Evidence map›Paper›PMID 37669629›Full record

ArticleJournal of vascular research2023

Emodin Inhibits the Indoxyl Sulfate-Induced trans-Differentiation of Vascular Smooth Muscle Cells through Upregulating Thrombospondin-1.

Weidong Zhang, Jing Chen, Xiao Tan, Pan Zhang, Xialian Xu, Xiaoqiang Ding, Shuan Zhao, Shi Jin

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of vascular research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Weidong ZhangDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China, zwd815849060@163.com.
Jing ChenDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Xiao TanDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Pan ZhangDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Xialian XuDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Xiaoqiang DingDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Shuan ZhaoDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Shi JinDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Zhongshan Hospital · CNFudan University · CNShanghai Blood Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIndoxyl sulfate (IS) is a protein-bound uremic toxin with vascular toxicity. The primary cause of death in uremic patients on maintenance hemodialysis is vascular disease, and it had been reported that vascular smooth muscle cells (VSMCs) trans-differentiation (VT) plays a vital role in the context of vascular diseases, but the underlying mechanisms remain obscure. Thrombospondin-1 (TSP-1) participates in vascular calcification by keeping the balance of extracellular matrix, but its role in IS-induced VT is unclear.

methodsIn this study, clinical specimens, animal models, and in vitro VSMCs were used to investigate the role of TSP-1 in IS induced VT and the potential therapeutic methods.

resultsWe found that TSP-1 was significantly decreased in arterial samples from uremic patients, animal models, and in VSMCs after IS treatment. Downregulation of TSP-1 sufficiently induced the trans-differentiation genotypes of VSMCs.

conclusionEmodin, the main monomer extracted from rhubarb, could alleviate IS-induced VT in vitro by upregulating TSP-1. Taken together, IS induces VT by downregulating TSP-1. Emodin might be a candidate drug to alleviate VT under IS treatment.

Indexed as

EmodinMuscle, Smooth, VascularAnimalsCells, CulturedCell TransdifferentiationHumansIndicanMyocytes, Smooth MuscleThrombospondin 1EmodinIndicanThrombospondin 1EmodinIndoxyl sulfateThrombospondin-1trans-differentiationVascular smooth muscle cells

Identifiers

PMID37669629
PMCPMC10614470
OpenAlexW4386467562

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.