ArticleProceedings of the National Academy of Sciences of the United States of America2023
Whole-genome detection using multivalent DNA-coated colloids.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Entropy-Driven Physical Amplification in Multivalent Biosensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Fluorescent carbon dot-based biosensor for the rapid and sensitive detection of Escherichia coli DNA.Scientific reports · 2026Article
- Reduced graphene oxide-based absorbance biosensors for detecting Escherichia coli DNA.Scientific reports · 2025Article
- Hopping and crawling DNA-coated colloids.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Weak-cooperative binding of a long single-stranded DNA chain on a surface.Nucleic acids research · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To minimize the incorrect use of antibiotics, there is a great need for rapid and inexpensive tests to identify the pathogens that cause an infection. The gold standard of pathogen identification is based on the recognition of DNA sequences that are unique for a given pathogen. Here, we propose and test a strategy to develop simple, fast, and highly sensitive biosensors that make use of multivalency. Our approach uses DNA-functionalized polystyrene colloids that distinguish pathogens on the basis of the frequency of selected short DNA sequences in their genome. Importantly, our method uses entire genomes and does not require nucleic acid amplification. Polystyrene colloids grafted with specially designed surface DNA probes can bind cooperatively to frequently repeated sequences along the entire genome of the target bacteria, resulting in the formation of large and easily detectable colloidal aggregates. Our detection strategy allows "mix and read" detection of the target analyte; it is robust and highly sensitive over a wide concentration range covering, in the case of our test target genome
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Registered trials
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