Evidence map›Paper›PMID 37669370›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Yusuke Watanabe, Yunce Wang, Yuki Tanaka, Akiyasu Iwase, Teruhisa Kawamura, Yumiko Saga, Kenta Yashiro, Hiroki Kurihara, Osamu Nakagawa

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Yusuke WatanabeDepartment of Molecular Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka 564-8565, Japan.ORCID 0000-0001-9486-4085
Yunce WangDepartment of Molecular Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka 564-8565, Japan.
Yuki TanakaDepartment of Molecular Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka 564-8565, Japan.
Akiyasu IwaseDepartment of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.ORCID 0000-0001-9095-5879
Teruhisa KawamuraLaboratory of Stem Cell & Regenerative Medicine, Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan.
Yumiko SagaMammalian Development Laboratory, Department of Gene Function and Phenomics, National Institute of Genetics, Mishima, Shizuoka 411-8582, Japan.ORCID 0000-0001-9198-5164
Kenta YashiroDivision of Anatomy and Developmental Biology, Department of Anatomy, Kyoto Prefectural University of Medicine, Kamigyo, Kyoto 602-8566, Japan.
Hiroki KuriharaDepartment of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.
Osamu NakagawaDepartment of Molecular Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka 564-8565, Japan.ORCID 0000-0002-3858-6903
Ritsumeikan University · JPNational Cerebral and Cardiovascular Center · JPThe University of Tokyo · JPKyoto Prefectural University of Medicine · JPNational Institute of Genetics · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cardiac crescent is the first structure of the heart and contains progenitor cells of the first heart field, which primarily differentiate into left ventricular cardiomyocytes. The interface between the forming cardiac crescent and extraembryonic tissue is known as the juxta-cardiac field (JCF), and progenitor cells in this heart field contribute to the myocardium of the left ventricle and atrioventricular canal as well as the epicardium. However, it is unclear whether there are progenitor cells that differentiate specifically into left ventricular cardiomyocytes. We have previously demonstrated that an enhancer of the gene encoding the Hey2 bHLH transcriptional repressor is activated in the ventricular myocardium during mouse embryonic development. In this study, we aimed to investigate the characteristics of cardiomyocyte progenitor cells and their cell lineages by analyzing

Indexed as

Heart VentriclesMyocytes, CardiacAnimalsBasic Helix-Loop-Helix ProteinsEmbryonic DevelopmentFemaleMiceMyocardiumPregnancyRegulatory Sequences, Nucleic AcidRepressor ProteinsTranscription FactorsBasic Helix-Loop-Helix ProteinsHey2 protein, mouseRepressor ProteinsTranscription Factorscell lineageHey2 enhancerjuxta-cardiac fieldprogenitor cellsventricular cardiomyocytes

Identifiers

PMID37669370
PMCPMC10500178
OpenAlexW4386453153

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.