ArticlePLoS neglected tropical diseases2023
Primary cerebral cystic echinococcosis in a child from Roman countryside: Source attribution and scoping review of cases from the literature.
Article in PLoS neglected tropical diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Epidemiological, Diagnostic, and Clinical Features of Intracranial Cystic Echinococcosis: A Systematic Review.Pathogens (Basel, Switzerland) · 2025Pooled it
- Clinical Characteristics, Management, and Outcomes of Intracranial Hydatid Cysts in Pakistan: A Narrative Synthesis.Cureus · 2026Review
- Pathogens of the Human Central Nervous System-the Major Protozoan Parasites and Helminths.Molecular neurobiology · 2026Review
- Geographic, demographic and economic burden of human cystic echinococcosis in Italy based on hospital discharge records (2015-2022).PLoS neglected tropical diseases · 2026Article
- Population-based ultrasound prevalence and risk factors for cystic echinococcosis in endemic Kazakhstan.PLoS neglected tropical diseases · 2026Article
- Intracranial hydatid cysts: A systematic review and proportion meta-analysis of surgical strategies and outcomes.Surgical neurology international · 2026Review
- Ultrasound-based population survey for abdominal cystic echinococcosis in Albania: Results from the NDTND project.PLoS neglected tropical diseases · 2025Article
- Unexplained subcutaneous swelling: Keep echinococcosis in mind! Report of two primary extrahepatic subcutaneous echinococcosis cases and literature review.PLoS neglected tropical diseases · 2025Review
- Cystic echinococcosis in Cyprus: historical retrospective and finding of 2Parasitology · 2024Article
- Rodent Gut Bacteria Coexisting with an Insect Gut Virus in Tapeworm Parasitic Cysts: Metagenomic Evidence of Microbial Selection in Extra-Intestinal Clinical Niches.Microorganisms · 2024Article
- Rodent Gut Bacteria Coexisting with an Insect Gut Virus in Parasitic Cysts: Metagenomic Evidence of Microbial Translocation and Co-adaptation in Spatially-Confined Niches.bioRxiv : the preprint server for biology · 2024Article
- Diagnosis and treatment experience of atypical hepatic cystic echinococcosis type 1 at a tertiary center in China.World journal of gastroenterology · 2024Article
- Clinical Pattern of Pediatric Hydatid Disease.Journal of Indian Association of Pediatric SurgeonsArticle
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11 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman cystic echinococcosis (CE) is a zoonotic parasitic infection caused by the larval stage of the species belonging to the Echinococcus granulosus sensu lato (s.l.) complex. Parasitic cysts causing human CE are mainly localized in the liver and in the lungs. In a smaller number of cases, larvae may establish in any organ or tissue, including the central nervous system (CNS). Cerebral CE (CCE) is rare but poses serious clinical challenges.
methodsThis study presents a case of CCE in a child living in the countryside near Rome (Italy), along with a comparative molecular analysis of the isolated cyst specimens from the patient and sheep of local farms. We also systematically searched the literature to summarize the most relevant epidemiological and clinical aspects of this uncommon localization.
findingsThe comparative molecular analysis confirmed that the infection was caused by E. granulosus sensu stricto (s.s.) (G3 genotype), and most likely acquired in the family farm. The literature search identified 2,238 cases of CCE. In 80.51% of cases, brain was the only localization and single CCE cysts were present in 84.07% of cases. Mean patients' age was 20 years and 70.46% were children. Cyst rupture was reported in 12.96% and recurrence of CCE after treatment in 9.61% of cases. Permanent disability was reported in 7.86% of cases, while death occurred in 6.21%. In case series reporting all CE localization, CCE represented 1.5% of all CE cases. In the few reports that identified at molecular level the CCE cyst, E. granulosus s.s. was found in 40% and E. canadensis in 60% of cases.
conclusionsWe report a rare case of CCE and evidenced the probable local origin of infection. The proportions of CE cases with uncommon localizations and with high impact on patients' lives have been globally neglected and should be included in the computation of the global burden of CE.
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