Evidence map›Paper›PMID 37669029›Full record

ArticleTherapeutic hypothermia and temperature management2024

Characterization of Circulating Cold Shock Proteins FGF21 and RBM3 in a Multi-Center Study of Pediatric Cardiac Arrest.

Jeremy R Herrmann, Ericka L Fink, Anthony Fabio, Rachel P Berger, Keri Janesko-Feldman, Kiersten Gorse, Robert S B Clark, Patrick M Kochanek, Travis C Jackson

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic hypothermia and temperature management, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jeremy R HerrmannSafar Center for Resuscitation Research, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-3342-0189
Ericka L FinkSafar Center for Resuscitation Research, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Anthony FabioGraduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Rachel P BergerDepartment of Pediatrics, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Keri Janesko-FeldmanSafar Center for Resuscitation Research, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kiersten GorseDepartment of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Robert S B ClarkSafar Center for Resuscitation Research, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Patrick M KochanekSafar Center for Resuscitation Research, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Travis C JacksonDepartment of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
University of Pittsburgh · USChildren's Hospital of Pittsburgh · USUniversity of South Florida · US

Funding

PEDIATRIC NEUROINTENSIVE CARE AND RESUSCITATION RESEARCHT32HD040686 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Robert S B Clark, PATRICK M KOCHANEK · 2000 to 2026
$7.1M
The Role of RNA Binding Motif 5 in Traumatic Brain InjuryR01NS105721 · NINDS · UNIVERSITY OF SOUTH FLORIDA · PI JACKSON, TRAVIS C · 2018 to 2022
$1.6M
NICHD NIH HHS T32 HD040686NINDS NIH HHS R01 NS105721
6 · The paper itself

Abstract

Fibroblast Growth Factor 21 (FGF21) is a neuroprotective hormone induced by cold exposure that targets the β-klotho co-receptor. β-klotho is abundant in the newborn brain but decreases rapidly with age. RNA-Binding Motif 3 (RBM3) is a potent neuroprotectant upregulated by FGF21 in hypothermic conditions. We characterized serum FGF21 and RBM3 levels in patients enrolled in a prospective multi-center study of pediatric cardiac arrest (CA) via a secondary analysis of samples collected to evaluate brain injury biomarkers. Patients (

Indexed as

BiomarkersFibroblast Growth FactorsHeart ArrestHypothermia, InducedRNA-Binding ProteinsAdolescentChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleProspective StudiesBiomarkersFGF21 protein, humanfibroblast growth factor 21Fibroblast Growth FactorsRBM3 protein, humanRNA-Binding Proteinsassay validationcardiac arresthypothermiapediatricstargeted temperature management

Identifiers

PMID37669029
PMCPMC11391889
OpenAlexW4386438887

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.