ArticleHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2023
Prognostic Clinical Phenotypes of Patients with Acute Decompensated Heart Failure.
Article in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 7 citations in OpenAlex.
- Early Detection of Clinical Deterioration in ICU Patients With Respiratory Failure Receiving Vasoactive Support: A Machine Learning Approach to Identifying High-Risk Individuals.Health science reports · 2026Article
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- Emergency Department Serum Electrolyte Patterns in Paroxysmal Atrial Fibrillation.Journal of clinical laboratory analysis · 2025Article
- Post-load glucose is a stronger predictor of adverse pregnancy outcomes than first-trimester HbA1c in women without gestational diabetes.Journal of diabetes investigation · 2024Article
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5 authors at 5 institutions in 1 country.
Funding
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Abstract
introductionAcute decompensated heart failure (AHF) is a clinical syndrome with a poor prognosis.
aimThis study was conducted to identify clusters of inpatients with acute decompensated heart failure that shared similarities in their clinical features.
methodsWe analyzed data from a cohort of patients with acute decompensated heart failure hospitalized between February 2013 and January 2017 in a Department of Cardiology. Patients were clustered using factorial analysis of mixed data. The clusters (phenotypes) were then compared using log-rank tests and profiled using a logistic model. In total, 458 patients (255; 55.7% male) with a mean (SD) age of 72.7 (11.1) years were included in the analytic dataset. The demographic, clinical, and laboratory features were included in the cluster analysis.
resultsThe two clusters were significantly different in terms of time to mortality and re-hospitalization (all P < 0.001). Cluster profiling yielded an accurate discriminating model (AUC = 0.934). Typically, high-risk patients were elderly females with a lower estimated glomerular filtration rate and hemoglobin on admission compared to the low-risk phenotype. Moreover, the high-risk phenotype had a higher likelihood of diabetes type 2, transient ischemic attack/cerebrovascular accident, previous heart failure or ischemic heart disease, and a higher serum potassium concentration on admission. Patients with the high-risk phenotype were of higher New York Heart Association functional classes and more positive in their medication history.
conclusionsThere are two phenotypes among patients with decompensated heart failure, high-risk and low-risk for mortality and re-hospitalization. They can be distinguished by easy-to-measure patients' characteristics.
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