Evidence map›Paper›PMID 37668723›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2024

Linking connectivity of deep brain stimulation of nucleus accumbens area with clinical depression improvements: a retrospective longitudinal case series.

Simona Leserri, Alba Segura-Amil, Andreas Nowacki, Ines Debove, Katrin Petermann, Lea Schäppi, Maria Giulia Preti, Dimitri Van De Ville, Claudio Pollo, Sebastian Walther and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Simona Leserri *Department of Neurosurgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Alba Segura-Amil *Department of Neurosurgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Andreas NowackiDepartment of Neurosurgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Ines DeboveDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Katrin PetermannDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Lea SchäppiTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Maria Giulia PretiNeuro-X Institute, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Dimitri Van De VilleNeuro-X Institute, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Claudio Pollo *Department of Neurosurgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Sebastian Walther *Translational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
T A Khoa Nguyen *Department of Neurosurgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. thuyanhkhoa.nguyen@insel.ch.ORCID http://orcid.org/0000-0003-0577-5035
University of Bern · CHUniversity of Geneva · CH

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 186142
6 · The paper itself

Abstract

Treatment-resistant depression is a severe form of major depressive disorder and deep brain stimulation is currently an investigational treatment. The stimulation's therapeutic effect may be explained through the functional and structural connectivities between the stimulated area and other brain regions, or to depression-associated networks. In this longitudinal, retrospective study, four female patients with treatment-resistant depression were implanted for stimulation in the nucleus accumbens area at our center. We analyzed the structural and functional connectivity of the stimulation area: the structural connectivity was investigated with probabilistic tractography; the functional connectivity was estimated by combining patient-specific stimulation volumes and a normative functional connectome. These structural and functional connectivity profiles were then related to four clinical outcome scores. At 1-year follow-up, the remission rate was 66%. We observed a consistent structural connectivity to Brodmann area 25 in the patient with the longest remission phase. The functional connectivity analysis resulted in patient-specific R-maps describing brain areas significantly correlated with symptom improvement in this patient, notably the prefrontal cortex. But the connectivity analysis was mixed across patients, calling for confirmation in a larger cohort and over longer time periods.

Indexed as

Deep Brain StimulationMajor Depressive DisorderDepressionFemaleHumansMagnetic Resonance ImagingNucleus AccumbensRetrospective StudiesConnectivityDeep brain stimulationDepression networksNucleus accumbens areaSubgenual anterior cingulate cortexTreatment-resistant depression

Identifiers

PMID37668723
PMCPMC10994999
OpenAlexW4386437796

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.