Evidence map›Paper›PMID 37668689›Full record

Trial reportEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2023

The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) levels following erector spinae plane block (ESPB) in posterior lumbar decompression: a randomized, controlled trial.

Małgorzata Domagalska, Bahadir Ciftsi, Piotr Janusz, Tomasz Reysner, Jerzy Kolasinski, Katarzyna Wieczorowska-Tobis, Grzegorz Kowalski

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07367009 (The Effect of the Combination of Adductor Canal Block and Anterior Femoral Cutaneous Nerve Block on Postoperative Inflammatory Biomarkers in Total Knee Arthroplasty), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07367009 active not recruitingnot on this mapstarted 2026, after this paper: background citation

The Effect of the Combination of Adductor Canal Block and Anterior Femoral Cutaneous Nerve Block on Postoperative Inflammatory Biomarkers in Total Knee Arthroplasty

Typeobservational_patient_registrySponsorFatih Sultan Mehmet Training and Research HospitalRan2026 to 2027Enrolled60ConditionsTotal Knee Anthroplasty
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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  16. Neutrophils and Anesthetic Drugs: Implications in Onco-Anesthesia.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Małgorzata DomagalskaChair and Department of Palliative Medicine, University of Medical Sciences, Os.Rusa 55, 61-245, Poznań, Poland. m.domagalska@icloud.com.ORCID http://orcid.org/0000-0002-9067-0969
Bahadir CiftsiDepartment of Anesthesiology and Reanimation, Istanbul Medipol University, Istanbul, Turkey.
Piotr JanuszDepartment of Spine Disorders and Pediatric Orthopedics, University of Medical Sciences, Poznań, Poland.
Tomasz ReysnerChair and Department of Palliative Medicine, University of Medical Sciences, Os.Rusa 55, 61-245, Poznań, Poland.
Jerzy KolasinskiKolasinski Clinic, Hair Clinic Poznan, 62-020, Swarzędz, Poland.
Katarzyna Wieczorowska-TobisChair and Department of Palliative Medicine, University of Medical Sciences, Os.Rusa 55, 61-245, Poznań, Poland.
Grzegorz KowalskiChair and Department of Palliative Medicine, University of Medical Sciences, Os.Rusa 55, 61-245, Poznań, Poland.
Poznan University of Medical Sciences · PLIstanbul Medipol University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNeutrophile-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are the inflammatory biomarkers of the stress response. In this study, we aimed to evaluate the effects of erector spinae plane block (ESPB) on posterior lumbar decompression and stabilization by comparing NLR, PLR, postoperative pain, opioid consumption, and functional recovery between sham block and ESPB.

methodsThis was a prospective, double-blinded, randomized controlled trial in a tertiary referral hospital. Sixty patients were randomized into two equal groups, each receiving either a sham block or ESPB. The primary outcome was the NLR and PLR 12 h and 24 h after lumbar posterior decompression and stabilization. The secondary outcomes were total opioid consumption and pain score 24 h postoperatively. Also, functional recovery determined by getting out of bed, verticalization, and walking by the balcony were reviewed as secondary outcomes.

resultsSignificant differences existed between the sham block and ESPB group in NLR (29.08 ± 12.29 vs. 16.97 ± 10.38; p < 0.0001) and PLR (556.77 ± 110.32 vs. 346.43 ± 117.34; p < 0.0001) 12 h after surgery. Also, there was a significant difference in NLR (p = 0.0466) and PLR (p < 0.0001) 24 h after surgery. In addition, there was a substantial difference in pain score, total opioid consumption, and functional recovery.

conclusionESPB performance during spinal surgery lowers NRL and PLR ratios 12 h and 24 h after surgery. In addition, ESPB provides better analgesia and improves functional recovery compared to sham block following posterior lumbar decompression and stabilization.

Indexed as

Analgesics, OpioidNerve BlockDecompressionHumansLymphocytesNeutrophilsPostoperative PainProspective StudiesAnalgesics, OpioidAnalgesiaErector spinae plane blockPain managementSpine surgeryStress responseSurgical site infection

Identifiers

PMID37668689
OpenAlexW4386439215

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.