Evidence map›Paper›PMID 37667870›Full record

SynthesisCritical reviews in food science and nutrition2023

Effects of prebiotics, probiotics, and synbiotics on the infant gut microbiota and other health outcomes: A systematic review.

Lynn E Ferro, Liana N Crowley, Kyle Bittinger, Elliot S Friedman, Jessica E Decker, Kathryn Russel, Sarah Katz, Jae Kyeom Kim, Jillian C Trabulsi

Open access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Critical reviews in food science and nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 3 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
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  7. Article
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  10. Article
  11. Live and Heat-InactivatedNutrients · 2026
    Article
  12. Review
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  16. Metabolic Engineering ofChem & bio engineering · 2026
    Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Lynn E FerroDepartment of Behavioral Health and Nutrition, University of Delaware, Newark, DE, USA.
Liana N CrowleyDepartment of Behavioral Health and Nutrition, University of Delaware, Newark, DE, USA.
Kyle BittingerDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0003-3472-5934
Elliot S FriedmanDivision of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jessica E DeckerDepartment of Behavioral Health and Nutrition, University of Delaware, Newark, DE, USA.
Kathryn RusselMetropolitan Area Neighborhood Nutrition Alliance, Philadelphia, PA, USA.
Sarah KatzDepartment of Reference and Instructional Services, University of Delaware, Newark, DE, USA.
Jae Kyeom KimDepartment of Behavioral Health and Nutrition, University of Delaware, Newark, DE, USA.
Jillian C TrabulsiDepartment of Behavioral Health and Nutrition, University of Delaware, Newark, DE, USA.
University of Delaware · USChildren's Hospital of Philadelphia · USNeighborhood Health · USUniversity of Pennsylvania · US

Funding

Secondary Analyses of RCT Data on Infant Formula and Nutritional ProgrammingR03HD094908 · NICHD · MONELL CHEMICAL SENSES CENTER · PI MENNELLA, JULIA ANNE, TRABULSI, JILLIAN CHRISTINE · 2018 to 2019
$173k
NICHD NIH HHS R03 HD094908
6 · The paper itself

Abstract

The primary aim of this review was to systematically evaluate the literature regarding the effect of pre-, pro-, or synbiotic supplementation in infant formula on the gastrointestinal microbiota. The Cochrane methodology for systematic reviews of randomized controlled trials (RCTs) was employed. Five databases were searched and 32 RCTs (2010-2021) were identified for inclusion: 20 prebiotic, 6 probiotic, and 6 synbiotic. The methods utilized to evaluate gastrointestinal microbiota varied across studies and included colony plating, fluorescence in situ hybridization, quantitative real-time polymerase chain reaction, or tagged sequencing of the 16S rRNA gene. Fecal

Indexed as

Gastrointestinal MicrobiomeProbioticsSynbioticsBifidobacteriumHumansInfantPrebioticsPrebioticsGastrointestinal microbiotainfantprebioticprobioticsynbioticsystematic review

Identifiers

PMID37667870
PMCPMC10480560
OpenAlexW4206838219

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.