Evidence map›Paper›PMID 37667837›Full record

ArticleObesity (Silver Spring, Md.)2024

Cognition in patients with post-bariatric hypoglycemia.

Alexa Puleio, Amanda Sheehan, Gail Musen, Mary Elizabeth Patti

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Obesity (Silver Spring, Md.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04430582 (Pilot Study - Cognition in Patients With Hypoglycemia, Without Diabetes), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04430582 completednot on this map

Pilot Study - Cognition in Patients With Hypoglycemia, Without Diabetes

TypeobservationalSponsorJoslin Diabetes CenterRan2020 to 2021Enrolled22ConditionsHypoglycemia, CognitionArmsCognitive Assessment (not diagnostic), ECG
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Diagnosis and Management of Post-Bariatric Hypoglycemia.Journal of the American Board of Family Medicine : JABFM
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alexa PuleioResearch Division, Joslin Diabetes Center, Boston, Massachusetts, USA.ORCID 0000-0002-9126-8314
Amanda SheehanResearch Division, Joslin Diabetes Center, Boston, Massachusetts, USA.
Gail MusenResearch Division, Joslin Diabetes Center, Boston, Massachusetts, USA.
Mary Elizabeth PattiResearch Division, Joslin Diabetes Center, Boston, Massachusetts, USA.ORCID 0000-0002-8163-3429
Joslin Diabetes Center · US

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5M
Mechanisms of Post-Bariatric HypoglycemiaR01DK121995 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PATTI, MARY E, SANDOVAL, DARLEEN A. · 2019 to 2022
$2.8M
NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R01 DK121995
6 · The paper itself

Abstract

objectiveBariatric surgery, a highly effective treatment for obesity and associated comorbidities, may improve cognition and brain volume in parallel with cardiometabolic function. However, some post-bariatric individuals develop post-bariatric hypoglycemia (PBH), which can be frequent and severe. The impact of recurrent hypoglycemia on cognition in PBH is unknown. The objective of this study was to determine whether individuals with PBH display reduced cognitive function compared with postsurgical counterparts without hypoglycemia.

methodsFourteen adults with a history of Roux-en-Y gastric bypass with hypoglycemia (PBH+, n = 7) or without PBH (PBH-, n = 7) completed assessments of memory, executive function, attention, and psychomotor speed.

resultsPBH+ individuals displayed significantly decreased performance in category fluency (p < 0.01), category switching (p < 0.01), and category switching accuracy (p < 0.01), compared with PBH- individuals. Performance in the first (p = 0.03) and third intervals (p = 0.045) of verbal fluency was significantly lower in PBH+ individuals versus PBH- individuals. All other assessments did not differ.

conclusionsPBH+ individuals may be at greater risk for cognitive impairment compared with PBH- individuals, as suggested by impaired semantic processing and cognitive flexibility, as well as greater difficulty initiating and sustaining word retrieval.

Indexed as

Bariatric SurgeryGastric BypassHypoglycemiaObesity, MorbidAdultCognitionHumansObesity

Identifiers

PMID37667837
PMCPMC10912358
OpenAlexW4386438706

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.