Evidence map›Paper›PMID 37667771›Full record

ArticleInternational journal of nanomedicine2023

Carrier-Free Binary Self-Assembled Nanomedicines Originated from Traditional Herb Medicine with Multifunction to Accelerate MRSA-Infected Wound Healing by Antibacterial, Anti-Inflammation and Promoting Angiogenesis.

Jihui Lu, Zhijia Wang, Desheng Cai, Xiaoyu Lin, Xuemei Huang, Zhihua Yuan, Yaozhi Zhang, Haimin Lei, Penglong Wang

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jihui LuSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, People's Republic of China.
Zhijia WangSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, People's Republic of China.
Desheng CaiSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, People's Republic of China.
Xiaoyu LinSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, People's Republic of China.
Xuemei HuangSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, People's Republic of China.
Zhihua YuanSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, People's Republic of China.
Yaozhi ZhangSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, People's Republic of China.
Haimin LeiSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, People's Republic of China.
Penglong WangSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, People's Republic of China.
Beijing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Deaths from bacterial infections have risen year by year. This trend is further aggravated as the overuse antibiotics and the bacterial resistance to all known antibacterial agents. Therefore, new therapeutic alternatives are urgently needed. Methods: Enlightenment the combination usage of traditional herb medicine, one carrier-free binary nanoparticles (GA-BBR NPs) was discovered, which was self-assembled from gallic acid and berberine through electrostatic interaction, π-π stacking and hydrophobic interaction; and it could be successfully prepared by a green, cost-effective and "one-pot" preparation process. Results: The nanoparticles exhibited strong antibacterial activity and biofilm removal ability against multidrug-resistant Conclusion: GA-BBR NPs originated from the drug combination has potential clinical transformation value, and this study provides a new idea for the design of carrier-free nanomedicine derived from natural herbals.

Indexed as

BerberineMethicillin-Resistant Staphylococcus aureusAnti-Bacterial AgentsAnti-Inflammatory AgentsExcipientsNanomedicineAnti-Bacterial AgentsAnti-Inflammatory AgentsBerberineExcipientsangiogenesisantibacterialanti-inflammatorycarrier-free binary self-assembliesnatural herbal ingredientswound healing

Identifiers

PMID37667771
PMCPMC10475309
OpenAlexW4386295319

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.