ArticleBMC public health2023
Heavy metals in drinking water and periodontitis: evidence from the national oral health survey from China.
Article in BMC public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Ferroptosis and macrophage efferocytosis in periodontitis: Biological insights and therapeutic advances.Virulence · 2025Review
- Neighborhood environmental burden and the elderly's complete edentulism prevalence in the US.BMC public health · 2025Article
- Public Health Concerns at the Intersection of Drinking Water Contamination and Low Healthcare Access in Maine.Maine policy review · 2025Article
- Association Between Ethylene Oxide Exposure and Complete Edentulism in United States Adults.Life (Basel, Switzerland) · 2025Article
- Reconstructing smoking history through dental cementum analysis - a preliminary investigation on modern and archaeological teeth.PloS one · 2025Article
- Copper Chelation Therapy Attenuates Periodontitis Inflammation through the Cuproptosis/Autophagy/Lysosome Axis.International journal of molecular sciences · 2024Article
- Association between exposure to environmental pollutants and increased oral health risks, a comprehensive review.Frontiers in public health · 2024Review
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Authors and funding
21 authors at 10 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPeriodontitis has become an increasingly important public health issue, coupled with a high economic burden for prevention and treatment. Exposure to essential trace heavy metals has been associated with various diseases; however, the relationships between essential trace heavy metals and periodontitis remain inconclusive.
objectivesTo investigate the association between essential trace heavy metals in tap water and periodontitis in a nationally representative sample in China.
methodsWe conducted a nationwide study including 1348 participants from the Fourth National Oral Health Survey in the 2015-2016 period. The trace heavy metals concentration was measured in the local pipeline terminal tap water. Periodontitis was diagnosed according to the classification scheme proposed at the 2018 world workshop on the classification of periodontal and peri-implant diseases and conditions. We used weighted multivariable logistic regression to estimate the association between essential trace heavy metals and the risk of periodontitis. We additionally used spline analysis to explore the possible nonlinear dose-response associations.
resultsPeriodontitis patients were exposed to higher concentrations of essential trace heavy metals. In adjusted models, for 1 SD increase in the concentration of iron, manganese, and copper in tap water, the risk of periodontitis increased by 30% (OR: 1.30, 95%CI: 1.12-1.50), 20% (OR: 1.20, 95%CI: 1.03-1.41), and 20% (OR: 1.20, 95%CI: 1.04-1.39), respectively. Stratified analyses demonstrated that the associations between essential trace heavy metals and periodontitis were higher in females, elders, and rural residents. Spline analysis revealed nonlinear exposure-response relationships between periodontitis and exposure to iron, manganese, and copper in tap water.
conclusionsExposures to essential trace heavy metals in drinking water were associated with greater odds of periodontitis. Given the growing burden of periodontitis, our study sheds light on tailored public health policies for improving drinking water standards to alleviate periodontitis impairment.
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