ArticleParasites & vectors2023
Bartonella infections are prevalent in rodents despite efficient immune responses.
Article in Parasites & vectors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Bartonella quintana endocarditis presenting with severe coombs-positive anemia: a case report.BMC cardiovascular disorders · 2026Article
- Variability in infection dynamics emerges from the interplay between unique host and pathogen characteristics.Scientific reports · 2025Article
- Pathogen contingency loci and the evolution of host specificity: Simple sequence repeats mediate Bartonella adaptation to a wild rodent host.PLoS pathogens · 2024Article
- Epidemiology of Bartonella henselae infection in pet and stray cats in Croatia with risk factors analysis.Parasites & vectors · 2024Article
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Authors and funding
11 authors at 7 institutions in 4 countries.
Funding
Abstract
backgroundPathogens face strong selection from host immune responses, yet many host populations support pervasive pathogen populations. We investigated this puzzle in a model system of Bartonella and rodents from Israel's northwestern Negev Desert. We chose to study this system because, in this region, 75-100% of rodents are infected with Bartonella at any given time, despite an efficient immunological response. In this region, Bartonella species circulate in three rodent species, and we tested the hypothesis that at least one of these hosts exhibits a waning immune response to Bartonella, which allows reinfections.
methodsWe inoculated captive animals of all three rodent species with the same Bartonella strain, and we quantified the bacterial dynamics and Bartonella-specific immunoglobulin G antibody kinetics over a period of 139 days after the primary inoculation, and then for 60 days following reinoculation with the same strain.
resultsContrary to our hypothesis, we found a strong, long-lasting immunoglobulin G antibody response, with protective immunological memory in all three rodent species. That response prevented reinfection upon exposure of the rodents to the same Bartonella strain.
conclusionsThis study constitutes an initial step toward understanding how the interplay between traits of Bartonella and their hosts influences the epidemiological dynamics of these pathogens in nature.
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Registered trials
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