ArticleBMC biology2023
Cuticular competing endogenous RNAs regulate insecticide penetration and resistance in a major agricultural pest.
Article in BMC biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 33 citations in OpenAlex.
- MicroRNA Lse-novel_mir63 regulates metamorphosis and fumigant tolerance by targeting CYP4G249 in Lasioderma serricorne.Pest management science · 2026Article
- Lecithin Exhibits Rapid Contact Toxicity AgainstInsects · 2026Article
- Multi-omics insights into mosquito insecticide resistance for integrated vector management.PeerJ · 2026Review
- Cuticle thickening mediates insecticide penetration resistance in Spodoptera litura.Journal of advanced research · 2025Article
- Cuticle protein mediates the evolution of stress resistance by generating a decoy circular RNA in spider mite.Science advances · 2025Article
- Screening the Resistance of MaleInsects · 2025Article
- A Leg Cuticle Protein Enhances the Resistance ofInternational journal of molecular sciences · 2025Article
- Ultrastructure and Transcriptome Analysis of the Larval Integument in Solitary and Gregarious Phases ofInsects · 2025Article
- Comparative Population Biology and Related Gene Expression in the Beta-Cypermethrin-Resistant Strains ofInsects · 2024Article
- Spatio-temporal characterization of phenotypic resistance in malaria vector species.BMC biology · 2024Article
- Insights into the role of non-coding RNAs in the development of insecticide resistance in insects.Frontiers in genetics · 2024Review
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe continuously developing pesticide resistance is a great threat to agriculture and human health. Understanding the mechanisms of insecticide resistance is a key step in dealing with the phenomenon. Insect cuticle is recently documented to delay xenobiotic penetration which breaks the previous stereotype that cuticle is useless in insecticide resistance, while the underlying mechanism remains scarce.
resultsHere, we find the integument contributes over 40.0% to insecticide resistance via different insecticide delivery strategies in oriental fruit fly. A negative relationship exists between cuticle thickening and insecticide penetration in resistant/susceptible, also in field strains of oriental fruit fly which is a reason for integument-mediated resistance. Our investigations uncover a regulator of insecticide penetration that miR-994 mimic treatment causes cuticle thinning and increases susceptibility to malathion, whereas miR-994 inhibitor results in opposite phenotypes. The target of miR-994 is a most abundant cuticle protein (CPCFC) in resistant/susceptible integument expression profile, which possesses capability of chitin-binding and influences the cuticle thickness-mediated insecticide penetration. Our analyses find an upstream transcriptional regulatory signal of miR-994 cascade, long noncoding RNA (lnc19419), that indirectly upregulates CPCFC in cuticle of the resistant strain by sponging miR-994. Thus, we elucidate the mechanism of cuticular competing endogenous RNAs for regulating insecticide penetration and demonstrate it also exists in field strain of oriental fruit fly.
conclusionsWe unveil a regulatory axis of lnc19419 ~ miR-994 ~ CPCFC on the cuticle thickness that leads to insecticide penetration resistance. These findings indicate that competing endogenous RNAs regulate insecticide resistance by modulating the cuticle thickness and provide insight into the resistance mechanism in insects.
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