Evidence map›Paper›PMID 37667256›Full record

ArticleBMC medicine2023

Triangulating evidence from observational and Mendelian randomization studies of ketone bodies for cognitive performance.

Wichanon Sae-Jie, Suangsuda Supasai, Mika Kivimaki, Jackie F Price, Andrew Wong, Meena Kumari, Jorgen Engmann, Tina Shah, Amand F Schmidt, Tom R Gaunt and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Wichanon Sae-JieDepartment of Mathematics, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand.
Suangsuda SupasaiDepartment of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand.
Mika KivimakiUCL Brain Sciences, University College London, 149 Tottenham Court Road, London, W1T 7NF, UK.
Jackie F PriceUsher Institute, University of Edinburgh, Edinburgh, EH8 9AG, UK.
Andrew WongMRC Unit Lifelong Health and Ageing at UCL, London, UK.
Meena KumariInstitute of Cardiovascular Science, Faculty of Population Health, University College London, London, WC1E 6BT, UK.
Jorgen EngmannInstitute of Cardiovascular Science, Faculty of Population Health, University College London, London, WC1E 6BT, UK.
Tina ShahInstitute of Cardiovascular Science, Faculty of Population Health, University College London, London, WC1E 6BT, UK.
Amand F SchmidtInstitute of Cardiovascular Science, Faculty of Population Health, University College London, London, WC1E 6BT, UK.
Tom R GauntMRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK.
Aroon HingoraniInstitute of Cardiovascular Science, Faculty of Population Health, University College London, London, WC1E 6BT, UK.
Pimphen CharoenInstitute of Cardiovascular Science, Faculty of Population Health, University College London, London, WC1E 6BT, UK. pimphen.cha@mahidol.edu.
UCLEB Consortium
University College London · GBMahidol University · THBritish Heart Foundation · GBUniversity of Bristol · GBUniversity of Edinburgh · GBUniversity of Essex · GB

Funding

Education, socioeconomic status and Aging: transitions from multimorbidity to functional limitations and mortalityR01AG056477 · NIA · UNIVERSITY COLLEGE LONDON · PI KIVIMAKI, MIKA J, SINGH-MANOUX, ARCHANA · 2018 to 2022
$2.8M
British Heart Foundation PG/22/10989Medical Research Council MC_UU_00011/4Medical Research Council MR/R024227/1Medical Research Council MR/S011676/1NIA NIH HHS R01 AG056477Wellcome TrustWellcome Trust 221854/Z/20/Z
6 · The paper itself

Abstract

backgroundKetone bodies (KBs) are an alternative energy supply for brain functions when glucose is limited. The most abundant ketone metabolite, 3-β-hydroxybutyrate (BOHBUT), has been suggested to prevent or delay cognitive impairment, but the evidence remains unclear. We triangulated observational and Mendelian randomization (MR) studies to investigate the association and causation between KBs and cognitive function.

methodsIn observational analyses of 5506 participants aged ≥ 45 years from the Whitehall II study, we used multiple linear regression to investigate the associations between categorized KBs and cognitive function scores. Two-sample MR was carried out using summary statistics from an in-house KBs meta-analysis between the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium and Kettunen et al. (N = 45,031), and publicly available summary statistics of cognitive performance and Alzheimer's disease (AD) from the Social Science Genetic Association Consortium (N = 257,841), and the International Genomics of Alzheimer's Project (N = 54,162), respectively. Both strong (P < 5 × 10

resultsBOHBUT was positively associated with general cognitive function (β = 0.26, P = 9.74 × 10

conclusionsTriangulation of evidence suggests that BOHBUT has a beneficial effect on cognitive performance. Our findings raise the hypothesis that increased BOHBUT may improve general cognitive functions, delaying cognitive impairment and reducing the risk of AD.

Indexed as

Alzheimer DiseaseKetone Bodies3-Hydroxybutyric AcidCognitionHumansKetonesMendelian Randomization AnalysisMiddle Aged3-Hydroxybutyric AcidKetone BodiesKetonesAlzheimer’s diseaseCognitive performanceKetone bodiesMendelian randomization

Identifiers

PMID37667256
PMCPMC10478491
OpenAlexW4386424352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.