ArticleGenome biology2023
Pervasive under-dominance in gene expression underlying emergent growth trajectories in Arabidopsis thaliana hybrids.
Article in Genome biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 6 citations in OpenAlex.
- Expression heterosis in the abaca (Musa textilis Née) BCBMC genomics · 2026Article
- The genetic architecture of gene expression regulation in aFrontiers in plant science · 2025Article
- High- or Low-Yielding FInternational journal of molecular sciences · 2024Article
- Pervasive under-dominance in gene expression underlying emergent growth trajectories in Arabidopsis thaliana hybrids.Genome biology · 2023Article
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
backgroundComplex traits, such as growth and fitness, are typically controlled by a very large number of variants, which can interact in both additive and non-additive fashion. In an attempt to gauge the relative importance of both types of genetic interactions, we turn to hybrids, which provide a facile means for creating many novel allele combinations.
resultsWe focus on the interaction between alleles of the same locus, i.e., dominance, and perform a transcriptomic study involving 141 random crosses between different accessions of the plant model species Arabidopsis thaliana. Additivity is rare, consistently observed for only about 300 genes enriched for roles in stress response and cell death. Regulatory rare-allele burden affects the expression level of these genes but does not correlate with F
conclusionsOur study underscores under-dominance as the predominant gene action associated with emergence of rosette growth trajectories in the A. thaliana hybrid model. Our work lays the foundation for understanding molecular mechanisms and evolutionary forces that lead to dominance complementation of rare regulatory alleles.
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