ArticleBMC psychiatry2023
Transdiagnostic considerations of the relationship between reward sensitivity and psychopathological symptoms - a cross-lagged panel analysis.
Article in BMC psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07388004 (Rewiring Expectations and Amplifying Rewards), which is not on this map. Cited by 10 papers.
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The trial behind it
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Rewiring Expectations and Amplifying Rewards: A Study Protocol for a Randomized Controlled Trial of Mechanism-Based Group Psychotherapy for Major Depressive Disorder
Who cites it
10 citing papers in PubMed.
- Aberrant functional connectivity of the globus pallidus in the modulation of the relationship between childhood trauma and major depressive disorder.Journal of psychiatry & neuroscience : JPNTrial
- Linking childhood adversity with borderline and depressive symptoms: the role of reward processing.European journal of psychotraumatology · 2026Article
- Reward Deficits in Co-Occurring Social Anxiety and Depression: The Roles of Anhedonia, Boredom, Loneliness, and COVID-19 Social Restriction.Journal of clinical psychology · 2026Article
- What to target? Interventions to modulate key mechanisms underlying the trajectories of affective disorders in the transregional Collaborative Research Center 393.Der Nervenarzt · 2026Review
- Multiple dimensions of reward-sensitivity and cognitive control relate to psychopathology: an exploratory structural equation modeling approach.Frontiers in psychology · 2026Article
- Trait reward sensitivity and behavioral motivation are associated with connectivity between the default mode network and the striatum during reward anticipation.bioRxiv : the preprint server for biology · 2025Article
- Factors associated with mental health resilience in the child, adolescent and adult offspring of depressed parents: A systematic literature review.Journal of affective disorders reports · 2025Article
- Lower reward sensitivity in frontostriatal stroke: Influence of depression and resting-state functional connectivity.Cognitive, affective & behavioral neuroscience · 2025Article
- A Systematic Review: Investigating Biomarkers of Anhedonia and Amotivation in Depression and Cannabis Use.JAACAP open · 2025Review
- Reviewing explore/exploit decision-making as a transdiagnostic target for psychosis, depression, and anxiety.Cognitive, affective & behavioral neuroscience · 2024Review
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2 authors.
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Abstract
backgroundReward sensitivity constitutes a potential key mechanism regarding the etiology and maintenance of mental disorders, especially depression. However, due to a lack of longitudinal studies, the temporal dynamics are not clear yet. Although some evidence indicates that reward processing could be a transdiagnostic mechanism of disorders, these observations could be also a product of comorbidity with depression. This study aimed at investigating the temporal dynamics of reward sensitivity and the course of psychopathological symptoms in a longitudinal investigation, while taking a possible mediating role of depression into account.
methodsWe conducted a three-wave longitudinal online survey with a 4-week interval. A total of N = 453 participants filled out all three questionnaires. Reward sensitivity was assessed with the Positive Valence System Scale-21 (PVSS-21), depression with the Patient Health Questionnaire (PHQ-9), eating disorder symptoms with the Eating Disorder Examination-Questionnaire-8 (EDE-Q-8), social anxiety with the Mini-social phobia inventory (Mini-SPIN) and alcohol consumption with the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C). Cross-lagged panels and mediation analyses were calculated using path analyses.
resultsDepressive and eating disorder symptoms predicted reward insensitivity at later points in time. Effects were larger from T2 to T3. A bidirectional relationship concerning social anxiety was found. Higher alcohol consumption predicted higher reward sensitivity. Depression at T2 fully mediated the association between psychopathological symptoms at T1 and reward sensitivity at T3 for social anxiety and eating disorder symptoms.
conclusionsOur findings imply that reduced reward sensitivity seems to be a consequence rather than an antecedent of psychopathological symptoms. Comorbid depression plays a crucial role in other mental disorders regarding observed hyposensitivity towards rewards. Therefore, our results do not support a transdiagnostic notion of reward sensitivity, but they indicate a potential role of reward sensitivity for symptom persistence.
trial registrationThe study was preregistered at the Open Science Framework (OSF) ( https://archive.org/details/osf-registrations-6n3s8-v1 ; registration DOI https://doi.org/10.17605/OSF.IO/6N3S8 ).
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