Evidence map›Paper›PMID 37667085›Full record

ArticleAnnals of biomedical engineering2023

Trans-aortic Valvular Ejection Fraction for Monitoring Recovery of Patients with Ventricular Systolic Heart Failure.

Viswajith Siruvallur Vasudevan, Keshava Rajagopal, Jesus E Rame, James F Antaki

Abstract read
PubMed Publisher
In one paragraph

Article in Annals of biomedical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Viswajith Siruvallur VasudevanMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Keshava RajagopalDepartment of Cardiac Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Jesus E RameThomas Jefferson University Hospital, Philadelphia, PA, USA.
James F AntakiMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA. antaki@cornell.edu.ORCID http://orcid.org/0000-0002-5430-7353
Cornell University · USThomas Jefferson University Hospital · US

Funding

U.S. Army Medical Research Acquisition Activity W81XWH2010387
6 · The paper itself

Abstract

Durable mechanical circulatory support in the form of left ventricular (LV) assist device (LVAD) therapy is increasingly considered in the context of the recovery of native cardiac function. Progressive improvement in LV function may facilitate LVAD explantation and a resultant reduction in device-related risk. However, ascertaining LV recovery remains a challenge. In this study, we investigated the use of trans-aortic valvular flow rate and trans-LVAD flow rate to assess native LV systolic function using a well-established lumped parameter model of the mechanically assisted LV with pre-existing systolic dysfunction. Trans-aortic valvular ejection fraction (TAVEF) was specifically found to characterize the preload-independent contractility of the LV. It demonstrated excellent sensitivity to simulated pharmacodynamic stress tests and volume infusion tests. TAVEF may prove to be useful in the ascertainment of LV recovery in LVAD-supported LVs with pre-existing LV systolic dysfunction.

Indexed as

CardiomyopathiesHeart-Assist DevicesHeart FailureHeart Failure, SystolicAortic ValveHeart VentriclesHumansStroke VolumeVentricular Function, LeftAortic valve dynamicsContractilityDilated cardiomyopathyFrank-starlingLeft ventricular assist deviceRESTAGE-HFTrans-aortic valvular ejection fractionVentricular recoveryVentricular unloading

Identifiers

PMID37667085
OpenAlexW4386423722

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.