Evidence map›Paper›PMID 37667076›Full record

ArticleNeurocritical care2024

Predictors and Prognostic Impact of Hematoma Expansion in Infratentorial Cerebral Hemorrhage.

Debora Pezzini, Jawed Nawabi, Frieder Schlunk, Qi Li, Federico Mazzacane, Giorgio Busto, Elisa Scola, Francesco Arba, Laura Brancaleoni, Sebastiano Giacomozzi and 10 more

Abstract read
PubMed Publisher
In one paragraph

Article in Neurocritical care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 11 institutions in 5 countries.

Debora PezziniNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Piazzale Spedali Civili, 1, 25123, Brescia, Italy. d.pezzini@unibs.it.ORCID 0000-0003-1072-0063
Jawed NawabiDepartment of Radiology (CCM), Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin Institute of Health, Humboldt-Universitätzu Berlin, FreieUniversität Berlin, Berlin, Germany.
Frieder SchlunkBerlin Institute of Health (BIH), BIH Biomedical Innovation Academy, Berlin, Germany.
Qi LiDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Federico MazzacaneU.C. Malattie Cerebrovascolari e Stroke Unit, IRCCS Fondazione Mondino, Pavia, Italy.
Giorgio BustoNeuroradiology Unit, Department of Radiology, Careggi University Hospital, Florence, Italy.
Elisa ScolaNeuroradiology Unit, Department of Radiology, Careggi University Hospital, Florence, Italy.
Francesco ArbaStroke Unit, Careggi University Hospital, Florence, Italy.
Laura BrancaleoniIRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Neurologia e Rete Stroke Metropolitana, Ospedale Maggiore, Bologna, Italy.
Sebastiano GiacomozziIRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Neurologia e Rete Stroke Metropolitana, Ospedale Maggiore, Bologna, Italy.
Luigi SimonettiIRCCS Istituto delle Scienze Neurologiche di Bologna, UO (SSI) di Neuroradiologia, Ospedale Maggiore, Bologna, Italy.
Michele LaudisiClinica Neurologica, Dipartimento di Scienze Biomediche e Chirurgico Specialistiche, Università degli Studi di Ferrara, Ospedale Universitario S. Anna, Ferrara, Italy.
Anna CavalliniU.C. Malattie Cerebrovascolari e Stroke Unit, IRCCS Fondazione Mondino, Pavia, Italy.
Aristeidis H KatsanosDivision of Neurology, McMaster University/Population Health Research Institute, Hamilton, ON, Canada.
Ashkan ShoamaneshDivision of Neurology, McMaster University/Population Health Research Institute, Hamilton, ON, Canada.
Andrea ZiniIRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Neurologia e Rete Stroke Metropolitana, Ospedale Maggiore, Bologna, Italy.
Ilaria CasettaClinica Neurologica, Dipartimento di Scienze Biomediche e Chirurgico Specialistiche, Università degli Studi di Ferrara, Ospedale Universitario S. Anna, Ferrara, Italy.
Enrico FainardiNeuroradiology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.
Andrea MorottiNeurology Unit, Department of Neurological Sciences and Vision, ASST Spedali Civili, Brescia, Italy.
Alessandro PadovaniNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Piazzale Spedali Civili, 1, 25123, Brescia, Italy.
Ospedale Maggiore · ITAzienda Ospedaliero-Universitaria Careggi · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITFondazione FADOI · ITHumboldt-Universität zu Berlin · DEUniversity of Ferrara · ITNational and Kapodistrian University of Athens · GRPopulation Health Research Institute · CAThe Affiliated Yongchuan Hospital of Chongqing Medical University · CNUniversity of Brescia · ITUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHematoma expansion (HE) is common and predicts poor outcome in patients with supratentorial intracerebral hemorrhage (ICH). We investigated the predictors and prognostic impact of HE in infratentorial ICH.

methodsWe conducted a retrospective analysis of patients with brainstem and cerebellar ICH admitted at seven sites. Noncontrast computed tomography images were analyzed for the presence of hypodensities according to validated criteria, defined as any hypodense region strictly encapsulated within the hemorrhage with any shape, size, and density. Occurrence of HE (defined as > 33% and/or > 6-mL growth) and mortality at 90 days were the outcomes of interest. Their predictors were investigated using logistic regression with backward elimination at p < 0.1. Logistic regression models for HE were adjusted for baseline ICH volume, antiplatelet and anticoagulant treatment, onset to computed tomography time, and presence of hypodensities. The logistic regression model for mortality accounted for the ICH score and HE.

resultsA total of 175 patients were included (median age 75 years, 40.0% male), of whom 38 (21.7%) had HE and 43 (24.6%) died within 90 days. Study participants with HE had a higher frequency of hypodensities (44.7 vs. 24.1%, p = 0.013), presentation within 3 h from onset (39.5 vs. 24.8%, p = 0.029), and 90-day mortality (44.7 vs. 19.0%, p = 0.001). Hypodensities remained independently associated with HE after adjustment for confounders (odds ratio 2.44, 95% confidence interval 1.13-5.25, p = 0.023). The association between HE and mortality remained significant in logistic regression (odds ratio 3.68, 95% confidence interval 1.65-8.23, p = 0.001).

conclusionEarly presentation and presence of noncontrast computed tomography hypodensities were independent predictors of HE in infratentorial ICH, and the occurrence of HE had an independent prognostic impact in this population.

Indexed as

Cerebral HemorrhageTomography, X-Ray ComputedAgedFemaleHematomaHumansMalePrognosisRetrospective StudiesHypodensityInfratentorialIntracerebral hemorrhageNoncontrast computed tomographyStroke

Identifiers

PMID37667076
OpenAlexW4386439113

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.