ArticlePediatric radiology2023
Real-time ultrasound-derived fat fraction in pediatric population: feasibility validation with MR-PDFF.
Article in Pediatric radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Ultrasound-derived fat fraction for diagnosing hepatic steatosis: a systematic review and meta-analysis.European radiology · 2025Pooled it
- Diagnostic performance of ultrasound-derived fat fraction for detecting hepatic steatosis in patients with tumor-related liver disease.Abdominal radiology (New York) · 2026Article
- Quantitative ultrasound-derived fat fraction for hepatic steatosis in MASLD using liver biopsy as the reference standard: a dual-center study.European radiology · 2026Article
- Interplay of childhood metabolic dysfunction-associated steatotic liver disease and obesity in the development of youth-onset type 2 diabetes.World journal of clinical pediatrics · 2026Article
- Exploring the association between BMI and liver fat in children: a study using ultrasound-derived fat fraction (UDFF).Pediatric radiology · 2026Article
- Diagnostic performance of ultrasound-derived fat fraction for assessing steatotic liver disease with histopathology as the reference.Ultrasonography (Seoul, Korea) · 2026Article
- Trimester-specific reference values of ultrasound-derived fat fraction and automated point shear-wave elastography for liver assessment in healthy singleton pregnancies.Quantitative imaging in medicine and surgery · 2026Article
- Influence variables of ultrasound-derived fat fraction in liver fat content measurement: preprandial and postprandial states.Abdominal radiology (New York) · 2025Article
- Quantitative ultrasound-derived fat fraction for identifying pediatric patients with metabolic dysfunction-associated steatotic liver disease: a prospective study.Pediatric radiology · 2025Article
- Discovery of ultrasound-derived fat fraction as a non-invasive tool for MASLD diagnosis.European journal of medical research · 2025Article
- MR and Ultrasound for Liver Fat Assessment in Children: Techniques and Supporting Evidence.Journal of magnetic resonance imaging : JMRI · 2025Review
- Consistency and reliability of ultrasound-derived fat fraction in hepatic steatosis assessment: influence of posture and breathing variations.BMC medical imaging · 2025Article
- Ultrasound-derived fat fraction: a novel approach for assessing Wilson's disease-related hepatic steatosis.BMC gastroenterology · 2025Article
- Assessment of hepatic steatosis in children with metabolic dysfunction-associated steatotic liver disease using ultrasound derived fat fraction: first large-scale clinical evaluation.Quantitative imaging in medicine and surgery · 2025Article
- Quantifying changes in steatotic liver disease after bariatric surgery using ultrasound-derived fat fraction.Radiology advances · 2025Article
- Methods and Validation of Velacur Determined Fat Fraction in patients with MASLD.WFUMB ultrasound open · 2024Article
- Non-invasively differentiate non-alcoholic steatohepatitis by visualizing hepatic integrin αvβ3 expression with a targeted molecular imaging modality.World journal of hepatology · 2024Article
- A Systematic Review of Metabolic Syndrome: Key Correlated Pathologies and Non-Invasive Diagnostic Approaches.Journal of clinical medicine · 2024Review
- Ultrasound-estimated hepatorenal index: diagnostic performance and interobserver agreement for pediatric liver fat quantification.Pediatric radiology · 2024Article
- Quantitative ultrasound (QUS) in the evaluation of liver steatosis: data reliability in different respiratory phases and body positions.La Radiologia medica · 2024Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundNonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in children. To avoid limitations of liver biopsy and MRI, quantitative ultrasound has become a research focus. Ultrasound-derived fat fraction (UDFF) is based on a combination of backscatter coefficient and attenuation parameter.
objectiveThe objectives of the study were to determine (1) agreement between UDFF/MRI proton density fat fraction (MR-PDFF) and (2) whether BMI and age are predictive for UDFF. MATERIALS AND
methodsThis cross-sectional prospective study included a convenience sample of 46 children referred for clinically indicated abdominal MRI. MR-PDFF and five acquisitions of UDFF were collected. Intraclass correlation coefficient (ICC) and Bland-Altman analysis were used to assess agreement between MR-PDFF and UDFF. Receiver operating characteristic curves were calculated for UDFF prediction of liver steatosis (MR-PDFF ≥ 6%). Multivariable regression was performed to assess BMI and age as predictors for UDFF.
resultsTwenty-two participants were male, 24 were female, and the mean age was 14 ± 3 (range: 7-18) years. Thirty-six out of 46 participants had normal liver fat fraction <6%, and 10/46 had liver steatosis. UDFF was positively associated with MR-PDFF (ICC 0.92 (95% CI, 0.89-0.96). The mean bias between UDFF and MR-PDFF was 0.64% (95% LOA, -5.3-6.6%). AUROC of UDFF for steatosis was of 0.95 (95% CI, 0.89-0.99). UDFF cutoff of 6% had a sensitivity of 90% (95% CI, 55-99%) and a specificity of 94% (95% CI, 81-0.99%). BMI was an independent predictor of UDFF (correlation: 0.55 (95% CI, 0.35-0.95)).
conclusionsUDFF shows strong agreement with MR-PDFF in children. A UDFF cutoff of 6% provides good sensitivity and specificity for detection of MR-PDFF of ≥ 6%.
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