ArticleNature plants2023
Structural basis for abscisic acid efflux mediated by ABCG25 in Arabidopsis thaliana.
Article in Nature plants, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Functional Analysis ofPlants (Basel, Switzerland) · 2026Article
- Genome-Wide Analysis and Expression Profiles ofInternational journal of molecular sciences · 2026Article
- Integrated transcriptomic and metabolomic analyses reveal the ABC transporter-related genes and metabolites involved in seed aging of Platostoma palustre (Blume) A. J. Paton.BMC plant biology · 2026Article
- Molecular Mechanisms of the Phytohormone-Heat Shock Protein Pathway in Regulating Plant Thermotolerance.Plants (Basel, Switzerland) · 2025Review
- Research Progress on Rice-Blast-Resistance-Related Genes.Plants (Basel, Switzerland) · 2025Review
- The Evolution of Plant Hormones: From Metabolic Byproducts to Regulatory Hubs.International journal of molecular sciences · 2025Review
- A Non-Specific Phytohormone Regulatory Network inPlants (Basel, Switzerland) · 2025Article
- Conformational cycle and small-molecule inhibition mechanism of a plant ABCB transporter in lipid membranes.Science advances · 2025Article
- A key residue of the extracellular gate provides quality control contributing to ABCG substrate specificity.Nature communications · 2025Article
- Message hidden in α-helices-toward a better understanding of plant ABCG transporters' multispecificity.Plant physiology · 2025Article
- Structural insights into brassinosteroid export mediated by the Arabidopsis ABC transporter ABCB1.Plant communications · 2025Article
- Cryo-EM structure and molecular mechanism of the jasmonic acid transporter ABCG16.Nature plants · 2024Article
- Combined Toxicity of Multi-Walled Carbon Nanotubes and CuNanomaterials (Basel, Switzerland) · 2024Article
- Effects of Abscisic Acid on the Physiological and Biochemical Responses ofInternational journal of molecular sciences · 2024Article
- Research Progress in the Regulation of the ABA Signaling Pathway by E3 Ubiquitin Ligases in Plants.International journal of molecular sciences · 2024Review
- Identification and expression analysis of ATP-binding cassette (ABC) transporters revealed its role in regulating stress response in pear (Pyrus bretchneideri).BMC genomics · 2024Article
- Structural insights into AtABCG25, an angiosperm-specific abscisic acid exporter.Plant communications · 2024Article
- Transcriptome dynamics inFrontiers in plant science · 2024Article
- Unveiling the crucial roles of abscisic acid in plant physiology: implications for enhancing stress tolerance and productivity.Frontiers in plant science · 2024Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
Abscisic acid (ABA) is a phytohormone essential to the regulation of numerous aspects of plant growth and development. The cellular level of ABA is critical to its signalling and is determined by its rate of biosynthesis, catabolism and the rates of ABA transport. ABCG25 in Arabidopsis thaliana has been identified to be an ABA exporter and play roles in regulating stomatal closure and seed germination. However, its ABA transport mechanism remains unknown. Here we report the structures of ABCG25 under different states using cryo-electron microscopy single particle analysis: the apo state and ABA-bound state of the wild-type ABCG25 and the ATP-bound state of the ATPase catalytic mutant. ABCG25 forms a homodimer. ABA binds to a cone-shaped, cytosolic-facing cavity formed in the middle of the transmembrane domains. Key residues in ABA binding are identified and verified by a cell-based ABA transport assay. ATP binding leads to closing of the nucleotide-binding domains of opposing monomers and conformational transitions of the transmembrane domains. Together, these results provide insights into the substrate recognition and transport mechanisms of ABCG25 in Arabidopsis, and facilitate our understanding of the ABA transport and signalling pathway in plants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.