Evidence map›Paper›PMID 37666709›Full record

Observational studyJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society2024

Prospective evaluation of nontuberculous mycobacteria disease in cystic fibrosis: The design of the PREDICT study.

Stacey L Martiniano, Silvia M Caceres, Katie Poch, Noel M Rysavy, Valerie K Lovell, Emily Armantrout, Marion Jones, Margaret Anthony, Allison Keck, David P Nichols and 10 more

Registry-linked trialOpen access · hybridAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02073409 (Prospective Evaluation of a Standardized Approach to Diagnosis), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02073409 unknown statusnot on this map

Prospective Evaluation of a Standardized Approach to Diagnosis (PREDICT) and Treatment (PATIENCE) of Nontuberculous Mycobacteria Disease in Cystic Fibrosis

TypeobservationalSponsorNational Jewish HealthRan2013 to 2025Enrolled200ConditionsCystic Fibrosis
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. State-of-the-Art Review: Transformative Changes in the Care of People With Cystic Fibrosis: Implications for Infectious Diseases Specialists.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Stacey L MartinianoDepartment of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address: stacey.martiniano@childrenscolorado.org.
Silvia M CaceresDepartment of Medicine, National Jewish Health, Denver, CO 80206, USA.
Katie PochDepartment of Medicine, National Jewish Health, Denver, CO 80206, USA.
Noel M RysavyDepartment of Medicine, National Jewish Health, Denver, CO 80206, USA.
Valerie K LovellDepartment of Medicine, National Jewish Health, Denver, CO 80206, USA.
Emily ArmantroutDepartment of Medicine, National Jewish Health, Denver, CO 80206, USA.
Marion JonesDepartment of Medicine, National Jewish Health, Denver, CO 80206, USA.
Margaret AnthonyDepartment of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Allison KeckDepartment of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO 80045, USA.
David P NicholsCystic Fibrosis Foundation Therapeutics Development Network Coordinating Center, Seattle Children's Research Institute, Seattle, Washington, USA.
Jill M VandalfsenCystic Fibrosis Foundation Therapeutics Development Network Coordinating Center, Seattle Children's Research Institute, Seattle, Washington, USA.
Scott D SagelDepartment of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Brandie WagnerDepartment of Biostatistics and Informatics, Colorado School of Public Health University of Colorado Anschutz Medical Campus Aurora Colorado, USA.
Jing XieCystic Fibrosis Foundation Therapeutics Development Network Coordinating Center, Seattle Children's Research Institute, Seattle, Washington, USA.
Katie WeaverCystic Fibrosis Foundation Therapeutics Development Network Coordinating Center, Seattle Children's Research Institute, Seattle, Washington, USA.
Sonya L HeltsheCystic Fibrosis Foundation Therapeutics Development Network Coordinating Center, Seattle Children's Research Institute, Seattle, Washington, USA.
Charles L DaleyDepartment of Medicine, National Jewish Health, Denver, CO 80206, USA; Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Rebecca M DavidsonCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO 80206, USA.
Jerry A NickDepartment of Medicine, National Jewish Health, Denver, CO 80206, USA; Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Investigators of the Cystic Fibrosis NTM Consortium
National Jewish Health · USCystic Fibrosis Foundation · USChildren's Hospital Colorado · USColorado School of Public Health · US

Funding

Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss · 2010 to 2026
$21.4M
Viral-induced Adaptation of Neutrophil Response in ARDSR01HL090991 · NHLBI · NATIONAL JEWISH HEALTH · PI NICK, JERRY A · 2007 to 2010
$1.7M
Prospective Longitudinal Assessment of Culture-Independent Molecular Airway Markers of Nontuberculous MycobacteriaR01HL146228 · NHLBI · NATIONAL JEWISH HEALTH · PI HILL, JANE, NICK, JERRY A · 2019 to 2022
$1.7M
NHLBI NIH HHS R01 HL090991NHLBI NIH HHS R01 HL146228NIDDK NIH HHS P30 DK089507
6 · The paper itself

Abstract

backgroundNontuberculous mycobacteria (NTM) are an important cause of airway infections in people with cystic fibrosis (pwCF). Isolation of NTM from respiratory specimens of pwCF do not mandate treatment in the absence of clinical and radiologic features of NTM pulmonary disease (NTM-PD), as some pwCF clear the infection without treatment and others do not appear to progress to NTM-PD despite persistent infection. An evidence-based protocol to standardize diagnosis of NTM-PD is needed to systematically identify pwCF who may benefit from treatment.

methodsIn this multicenter observational study, eligible pwCF who are 6 years of age and older and who have had a recent positive NTM culture are systematically evaluated for NTM-PD. Participants are identified based on positive NTM culture results obtained during routine clinical care and following enrollment are evaluated for NTM-PD and CF-related comorbidities. Participants are followed in PREDICT until they meet NTM-PD diagnostic criteria and are ready to initiate NTM treatment, or until study termination. Active participants who have not met these criteria are re-consented every 5 years to enable long-term participation.

resultsThe primary endpoint will summarize the proportion of participants who meet the NTM-PD diagnosis definition. The time from enrollment to NTM-PD diagnosis will be derived from Kaplan-Meier estimates.

conclusionA prospective protocol to identify NTM-PD in pwCF will test if this standardized approach defines a cohort with signs and symptoms associated with NTM-PD, to assist with clinical decision making and to build a framework for future therapeutic trials.

trial registrationClinicalTrials.gov Identifier: NCT02073409.

Indexed as

Cystic FibrosisMycobacterium Infections, NontuberculousHumansNontuberculous MycobacteriaBiomarkersCFTR modulator therapyCystic fibrosisM. abscessusM. avium complexNontuberculous mycobacterial (NTM) pulmonary disease

Identifiers

PMID37666709
PMCPMC10907544
OpenAlexW4386415562

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.