Evidence map›Paper›PMID 37666668›Full record

ArticleLife science alliance2023

The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine.

Juan E Hernandez, Cristina Llorente, Shengyun Ma, Kiana T Miyamoto, Saptarshi Sinha, Scarlet Steele, Zihui Xiao, Ching-Jung Lai, Elina I Zuniga, Pradipta Ghosh and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Juan E HernandezDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID https://orcid.org/0000-0002-9386-2616
Cristina LlorenteDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.ORCID https://orcid.org/0000-0001-8135-9186
Shengyun MaDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID https://orcid.org/0000-0003-3368-9388
Kiana T MiyamotoDivision of Biological Sciences, University of California San Diego, La Jolla, CA, USA.ORCID https://orcid.org/0000-0002-4521-6644
Saptarshi SinhaDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Scarlet SteeleDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Zihui XiaoDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID https://orcid.org/0009-0002-5781-9423
Ching-Jung LaiDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Elina I ZunigaDivision of Biological Sciences, University of California San Diego, La Jolla, CA, USA.
Pradipta GhoshDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Bernd SchnablDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Wendy Jia Men HuangDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA wendyjmhuang@health.ucsd.edu.ORCID https://orcid.org/0000-0001-7425-8280
University of California San Diego · US

Funding

The Southernearch Center for ALPD and CirrhosisP50AA011999 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ANNA S. GUKOVSKAYA · 1999 to 2026
$45.8M
San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LARS ECKMANN, Bernd G. Schnabl · 2019 to 2026
$10.8M
Pathways in Biological Sciences Training ProgramT32GM133351 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Matthew Daugherty, Randolph Y. Hampton · 2020 to 2026
$9.9M
Predoctoral and Postdoctoral Training in Cancer Cell BiologyT32CA067754 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEAN Y.J. WANG · 1995 to 2026
$6.5M
Macrophage Polarization in Response to Infections and InflammationR01AI155696 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA, SAHOO, DEBASHIS · 2020 to 2024
$4.9M
The Role of the Intestinal Mycobiome in Alcoholic Liver DiseaseR01AA024726 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2018 to 2026
$3.9M
Modulation of Macrophage Polarization by Heterotrimeric G proteins: Implications of Gastrointestinal InflammationR01AI141630 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pradipta Ghosh · 2019 to 2026
$3.2M
Microbiome and Intestinal Innate Immune Response in Alcoholic Liver DiseaseR37AA020703 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2021 to 2026
$2.5M
Goblet cells and intestinal immune response in alcohol-associated liver diseaseR01AA029106 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ana Cristina Llorente Izquierdo · 2022 to 2026
$2.3M
Post-translational modifications in RORgt-dependent immune cell functionsR01GM124494 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HUANG, WENDY JIA MEN · 2017 to 2021
$2.0M
Microbiome as therapeutic target in alcoholic hepatitisU01AA026939 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FOUTS, DERRICK E, SCHNABL, BERND G. · 2018 to 2022
$1.7M
Network-Based Novel Therapeutics in Colorectal CancersUG3TR002968 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAS, SOUMITA, GHOSH, PRADIPTA · 2019 to 2021
$946k
BLRD VA I01 BX004594NCATS NIH HHS UG3 TR002968NCATS NIH HHS UG3 TR003355NCATS NIH HHS UH3 TR002968NCATS NIH HHS UH3 TR003355NCI NIH HHS T32 CA067754NIAAA NIH HHS P50 AA011999NIAAA NIH HHS R01 AA024726NIAAA NIH HHS R01 AA029106NIAAA NIH HHS R21 AA030654NIAAA NIH HHS R37 AA020703NIAAA NIH HHS U01 AA026939NIAID NIH HHS R01 AI141630NIAID NIH HHS R01 AI155696NIDDK NIH HHS P30 DK120515NIGMS NIH HHS R01 GM124494NIGMS NIH HHS T32 GM133351
6 · The paper itself

Abstract

PRMT5 is a type II arginine methyltransferase abundantly expressed in the colonic epithelium. It is up-regulated in inflammatory bowel disease and colorectal cancer. However, its role in mucosal defense against enteric infection has not been studied. Here, we report that

Indexed as

Enterobacteriaceae InfectionsIntestinesAnimalsColonIntracellular Signaling Peptides and ProteinsMiceProtein-Arginine N-MethyltransferasesIntracellular Signaling Peptides and ProteinsPRMT2 protein, humanProtein-Arginine N-Methyltransferases

Identifiers

PMID37666668
PMCPMC10477432
OpenAlexW4386415125

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.