Evidence map›Paper›PMID 37666547›Full record

ArticleBMJ open2023

Development of a core outcome set for ventilation trials in neurocritical care patients with acute brain injury: protocol for a Delphi consensus study of international stakeholders.

Jean Digitale, Gregory Burns, Nicholas Fong, Julian Boesel, Chiara Robba, Robert D Stevens, Raphaël Cinotti, Romain Pirracchio

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Jean DigitaleDepartment of Epidemiology and Biostatistics, University of California, San Francisco, California, USA.
Gregory BurnsDepartment of Respiratory Care, University of California, San Francisco, California, USA.
Nicholas FongAnesthesia and Perioperative Medicine, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0002-3412-0735
Julian BoeselDepartment of Neurology, Heidelberg University, Heidelberg, Germany.
Chiara RobbaNeurocritical Care Unit, Ospedale Policlinico San Martino, Genova, Italy.ORCID 0000-0003-1628-3845
Robert D StevensDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Raphaël CinottiAnaesthesia and Intensive Care Unit, Hôpital Laennec, Saint-Herblain, University Hospital of Nantes, Université de Nantes, CHU Nantes, Nantes, France.ORCID 0000-0001-9217-8532
Romain PirracchioDepartment of Epidemiology and Biostatistics, University of California, San Francisco, California, USA Romain.Pirracchio@ucsf.edu.ORCID 0000-0002-7007-4908
University of California, San Francisco · USHeidelberg University · DEHôpital Laennec · FRJohns Hopkins University · USOspedale Policlinico San Martino · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThere is little consensus and high heterogeneity on the optimal set of relevant clinical outcomes in research studies regarding extubation in neurocritical care patients with brain injury undergoing mechanical ventilation. The aims of this study are to: (1) develop a core outcome set (COS) and (2) reach consensus on a hierarchical composite endpoint for such studies. METHODS AND ANALYSIS: The study will include a broadly representative, international panel of stakeholders with research and clinical expertise in this field and will involve four stages: (1) a scoping review to generate an initial list of outcomes represented in the literature, (2) an investigator meeting to review the outcomes for inclusion in the Delphi surveys, (3) four rounds of online Delphi consensus-building surveys and (4) online consensus meetings to finalise the COS and hierarchical composite endpoint. ETHICS AND DISSEMINATION: This study received ethical approval from the French Society of Anesthesia and Critical Care Medicine Institutional Review Board (SFAR CERAR-IRB 00010254-2023-029). The study results will be disseminated through communication to stakeholders, publication in a peer-reviewed journal, and presentations at conferences. TRIAL REGISTRATION NUMBER: This study is registered with the Core Outcome Measures in Effectiveness Trials (COMET) Initiative.

Indexed as

Brain InjuriesRespirationAirway ExtubationDelphi TechniqueHumansRespiration, ArtificialReview Literature as Topicadult intensive & critical careneurological injuryprotocols & guidelinestrauma management

Identifiers

PMID37666547
PMCPMC10481746
OpenAlexW4386408463

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.