ArticleInternational journal of gynecological cancer : official journal of the International Gynecological Cancer Society2023
Prognostic value of lymphovascular space invasion according to the molecular subgroups in endometrial cancer.
Article in International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Preoperative CA125 and metabolic factors associated with high-risk pathology in endometrial cancer.Oncology letters · 2026Article
- Integration of L1CAM and β-catenin immunohistochemistry for prognostic risk stratification of endometrial carcinoma: a practical approach for resource-limited settings.Medical molecular morphology · 2026Article
- Review
- Substantial LVSI Is Independently Associated with Para-Aortic Nodal Metastasis in Patients Undergoing Laparoscopic Surgical Staging for Endometrial Cancer.Current oncology (Toronto, Ont.) · 2026Article
- Prognostic Impact of WHO 2020 Lymphovascular Space Invasion Categories in Endometrial Cancer: Substantial LVSI as an Independent Risk Factor and the Behavior of LVSI-Positive, Node-Negative Disease.The journal of obstetrics and gynaecology research · 2026Article
- Impact of the 2023 FIGO staging revision on MRI diagnostic accuracy in FIGO 2009 stage I endometrial cancer.Abdominal radiology (New York) · 2026Article
- Constructing a prediction model for lymph node metastasis in patients with incidental finding of endometrial cancer based on Fully-Connected Network.Journal of gynecologic oncology · 2026Article
- Clinicopathological and Molecular Characterization of High Grade Endometrial Carcinomas of No Specific Molecular Profile (NSMP) Stratified by ER Status.International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2026Article
- Analysis of Differences in the Classification of Endometrial Cancer Patients in Poland.Cancers · 2025Article
- Practical guidance for assessing and reporting lymphovascular space invasion (LVSI) in endometrial carcinoma.Histopathology · 2025Review
- Serous Ovarian Carcinoma: Detailed Analysis of Clinico-Pathological Characteristics as Prognostic Factors.Cancers · 2024Article
- Molecular Genetic Factors of Risk Stratification of Lymph Node Metastasis in Endometrial Carcinoma.Cancers · 2024Review
- Prognostic significance of lymphovascular space invasion in early-stage low-grade endometrioid endometrial cancer: a fifteen-year retrospective Chinese cohort study.World journal of surgical oncology · 2024Article
- Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveLymphovascular space invasion (LVSI) is a known prognostic factor for oncological outcome in endometrial cancer patients. However, little is known about the prognostic value of LVSI among the different molecular subgroups. The aim of this study was to determine the prognostic dependence of LVSI from the molecular signature.
methodsThis study included endometrial cancer patients who underwent primary surgical treatment between February 2004 and February 2016 at the Karolinska University Hospital, Sweden and the Bern University Hospital, Switzerland (KImBer cohort). All cases had complete molecular analysis performed on the primary tumor according to the WHO Classification of Tumors, 5th edition. LVSI was reviewed by reference pathologists for all pathology slides.
resultsA total of 589 endometrial cancer patients were included in this study, consisting of 40
conclusionThe presence of LVSI was associated with recurrence in each subgroup of patients with MMRd, p53abn, and NSMP endometrial cancer, and LVSI remained an independent predictor of recurrence in NSMP endometrial cancer patients.
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