Evidence map›Paper›PMID 37666527›Full record

ArticleInternational journal of gynecological cancer : official journal of the International Gynecological Cancer Society2023

Artificial intelligence and visual inspection in cervical cancer screening.

Carolyn Nakisige, Marlieke de Fouw, Johnblack Kabukye, Marat Sultanov, Naheed Nazrui, Aminur Rahman, Janine de Zeeuw, Jaap Koot, Arathi P Rao, Keerthana Prasad and 4 more

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06452004 (Prevention and Screening Intervention Project - Towards Elimination of Cervical Cancer), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06452004 naunknown statusnot on this map

Prevention and Screening Intervention Project - Towards Elimination of Cervical Cancer: Validation of Artificial Intelligence as Decision Support System in VIA

TypeinterventionalSponsorUniversity Medical Center GroningenRan2022 to 2025Enrolled600ConditionsHPV Infection, Cervix Cancer, Cervical DysplasiaArmsValidation of AI-DSS in Bangladesh, Validation of AI-DSS in Uganda, Validation of AI-DSS in India
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 4 countries.

Carolyn NakisigeGynaecologic Oncology, Uganda Cancer Institute, Kampala, Uganda carolyn.nakisige@uci.or.ug.ORCID 0000-0002-1497-8056
Marlieke de FouwGynecology, Leiden University Medical Center department of Gynecology, Leiden, Zuid-Holland, Netherlands.
Johnblack KabukyeUganda Cancer Institute, Kampala, Uganda.
Marat SultanovUniversity Medical Center Groningen, University of Groningen, Groningen, Netherlands, Groningen, Netherlands.
Naheed NazruiFRIENDSHIP, Dhaka, Bangladesh.
Aminur RahmanICDDRB Public Health Sciences Division, Dhaka, Dhaka District, Bangladesh.
Janine de ZeeuwUniversity Medical Center Groningen, University of Groningen, Groningen, Netherlands, Groningen, Netherlands.
Jaap KootUniversity Medical Center Groningen, University of Groningen, Groningen, Netherlands, Groningen, Netherlands.
Arathi P RaoPrasanna School of Public Health, Manipal Academy of Higher Education, Manipal, India, Manipal, India.
Keerthana PrasadManipal Academy of Higher Education School of Life Sciences, Manipal, Karnataka, India.
Guruvare ShyamalaManipal Academy of Higher Education - Mangalore Campus, Mangalore, Karnataka, India.
Premalatha SiddhartaGynecological Oncology, St John's National Academy of Health Sciences, Bangalore, Karnataka, India.
Jelle StekelenburgUniversity Medical Center Groningen, University of Groningen, Groningen, Netherlands, Groningen, Netherlands.
Jogchum Jan BeltmanGynaecology, LUMC, Leiden, Netherlands.
University Medical Center Groningen · NLManipal Academy of Higher Education · INLeiden University Medical Center · NLUganda Cancer Institute · UGInternational Centre for Diarrhoeal Disease Research · BDSt. John's National Academy of Health Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionVisual inspection with acetic acid is limited by subjectivity and a lack of skilled human resource. A decision support system based on artificial intelligence could address these limitations. We conducted a diagnostic study to assess the diagnostic performance using visual inspection with acetic acid under magnification of healthcare workers, experts, and an artificial intelligence algorithm.

methodsA total of 22 healthcare workers, 9 gynecologists/experts in visual inspection with acetic acid, and the algorithm assessed a set of 83 images from existing datasets with expert consensus as the reference. Their diagnostic performance was determined by analyzing sensitivity, specificity, and area under the curve, and intra- and inter-observer agreement was measured using Fleiss kappa values.

resultsSensitivity, specificity, and area under the curve were, respectively, 80.4%, 80.5%, and 0.80 (95% CI 0.70 to 0.90) for the healthcare workers, 81.6%, 93.5%, and 0.93 (95% CI 0.87 to 1.00) for the experts, and 80.0%, 83.3%, and 0.84 (95% CI 0.75 to 0.93) for the algorithm. Kappa values for the healthcare workers, experts, and algorithm were 0.45, 0.68, and 0.63, respectively.

conclusionThis study enabled simultaneous assessment and demonstrated that expert consensus can be an alternative to histopathology to establish a reference standard for further training of healthcare workers and the artificial intelligence algorithm to improve diagnostic accuracy.

Indexed as

Uterine Cervical NeoplasmsAcetic AcidArtificial IntelligenceEarly Detection of CancerFemaleHumansPhysical ExaminationSensitivity and SpecificityAcetic AcidCervical Cancer

Identifiers

PMID37666527
PMCPMC10579490
OpenAlexW4386423584

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.