ArticleIEEE transactions on bio-medical engineering2024
Focused Shear Wave Beam Propagation in Tissue-Mimicking Phantoms.
Article in IEEE transactions on bio-medical engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- A Handheld Probe for Focused Shear Wave Transient Elastography.Annals of biomedical engineering · 2026Article
- Focused Shear Wave Elastography to Assess Liver Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease.Gastro hep advances · 2026Article
- Design and application of a realistic and multifunctional retinal phantom for standardizing ophthalmic imaging systems.Communications engineering · 2025Article
- Mechanically anisotropic phantoms for magnetic resonance elastography.Magnetic resonance in medicine · 2025Article
- Collagen fibers quantification for liver fibrosis assessment using linear dichroism photoacoustic microscopy.Photoacoustics · 2025Article
- Integrated Difference Autocorrelation: A Novel Approach to Estimate Shear Wave Speed in the Presence of Compression Waves.IEEE transactions on bio-medical engineering · 2025Article
- Acoustic radiation force-induced longitudinal shear wave for ultrasound-based viscoelastic evaluation.Ultrasonics · 2024Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveUltrasound transient elastography (TE) technologies for liver stiffness measurement (LSM) utilize vibration of small, flat pistons, which generate shear waves that lack directivity. The most common cause for LSM failure in practice is insufficient shear wave signal at the needed depths. We propose to increase shear wave amplitude by focusing the waves into a directional beam. Here, we demonstrate the generation and propagation of focused shear wave beams (fSWBs) in gelatin.
methodsDirectional fSWBs are generated by vibration at 200-400 Hz of a concave piston embedded near the surface of gelatin phantoms and measured with high-frame-rate ultrasound imaging. Five phantoms with a range of stiffnesses are employed. Shear wave speeds assessed by fSWBs are compared with those by radiation-force-based methods (2D SWE). fSWB amplitudes are compared to predictions using an analytical model.
resultsfSWB-derived shear wave speeds are in good agreement with 2D SWE. The amplitudes of fSWBs are localized to the LSM region and are significantly greater than unfocused shear waves. Overall agreement with theory is observed, with some discrepancies in the theoretical source condition.
conclusionFocusing shear waves can increase the signal in the LSM region for TE. Challenges for translation include coupling piston vibration with the patient skin and increased attenuation in vivo compared to the phantoms employed here. SIGNIFICANCE: Fibrosis is the most predictive measure of patient outcome in non-alcoholic fatty liver disease. Increased shear wave amplitude in the LSM region can reduce fibrosis assessment failure rates by TE, thus reducing the need for invasive methods like biopsy.
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