ArticleJournal of gastroenterology2023
Global, regional, and national burden of liver cancer due to non-alcoholic steatohepatitis, 1990-2019: a decomposition and age-period-cohort analysis.
Article in Journal of gastroenterology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47 citing papers in PubMed, 53 citations in OpenAlex.
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- An analysis of the global, regional, and national burden of liver cirrhosis in older adults from 1990 to 2021.Medicine · 2026Article
- Global, regional and national burden of skin and subcutaneous diseases: a systematic analysis of the Global Burden of Disease Study 2021.International health · 2026Article
- Global disparities in liver cancer burden: an epidemiological and socioeconomic analysis using GBD 1990-2021 data.Discover oncology · 2026Article
- Global liver cancer burden attributed to high body mass index: trends, projections, and its relationship with socioeconomic development status (1990-2021).European journal of gastroenterology & hepatology · 2026Article
- Global, regional, and national burden and future projections of pancreatitis: A Joinpoint, APC, and ARIMA modeling analysis.Clinical and experimental medicine · 2026Article
- Trends in PCOS Incidence, Prevalence, and DALYs Across Five BRICS Nations, 1990-2050: A Decomposition, Age-Period-Cohort, and Bayesian Forecasting Analysis Based on GBD 2021.International journal of women's health · 2026Article
- China data on the burden of alcohol-associated liver cancer from 1990 to 2021: a systematic analysis from the global burden of disease study 2021.Ecancermedicalscience · 2026Article
- Temporal trends in prevalence of chronic liver disease among women of childbearing age from 1992 to 2021.Frontiers in global women's health · 2026Article
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- Global, regional, and National burden of falls among midlife women from 1990 to 2021 and projections to 2050: A systematic analysis for the global burden of disease study 2021.Aging clinical and experimental research · 2025Article
- Disease burden attributable to high temperature between 1990 and 2021 in South Asia and Southeast Asia, with projections to 2045.Tropical medicine and health · 2025Article
- Global, regional, and national burden and trends of endometriosis, 1990-2021: an analysis of the global burden of disease study 2021 and forecast to 2050.BMC women's health · 2025Article
- Comprehensive epidemiological analysis of chronic kidney disease in adolescents and young adults (ages 10-24 years) from 1990 to 2021.BMJ open · 2025Article
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- Global, regional, and National burden of metabolic dysfunction-associated steatohepatitis-related liver cancer in older adults: trends and cross-national inequality based on the global burden of disease study 2021.Discover oncology · 2025Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundIdentifying past temporal trends in non-alcoholic steatohepatitis (NASH)-associated liver cancer (NALC) can increase public awareness of the disease and facilitate future policy development.
methodsAnnual deaths and age-standardized death rates (ASDR) for NALC from 1990 to 2019 were collected from the Global Burden of Disease (GBD) 2019 study. The long-term trend and the critical inflection of mortality of NALC were detected by Joinpoint analysis. Age-period-cohort analysis was employed to evaluate the effects of age, period, and cohort. Last, decomposition analysis was used to reveal the aging and population growth effects for NALC burden.
resultsBetween 1990 and 2019, the ASDR of NALC witnessed an overall declining trend on a global scale, with a decrease in females and a stable trend in males. However, the global ASDR demonstrated a significant upward trend from 2010 to 2019. Southern sub-Saharan Africa and Southeast Asia have the highest NALC burdens, while high socio-demographic index (SDI) region experienced the fastest escalation of NALC burdens over 30 years. The decomposition analysis revealed that population growth and aging were the primary catalysts behind the increase in global NALC deaths. Age-period-cohort analyses showed that NALC mortality declined the fastest among females aged 40-45 years in high SDI region, accompanied by a deteriorating period effect trend during the period of 2010-2019.
conclusionThe global absolute deaths and ASDR of NALC have witnessed a rise in the past decade, with populations exhibiting considerable disparities based on sex, age, and region. Population growth, aging, and metabolism-related factors were the main factors behind the increase in global NALC deaths.
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