Evidence map›Paper›PMID 37665480›Full record

SynthesisReviews in endocrine & metabolic disorders2023

Vitamin D status and supplementation before and after Bariatric Surgery: Recommendations based on a systematic review and meta-analysis.

Andrea Giustina, Luigi di Filippo, Antonio Facciorusso, Robert A Adler, Neil Binkley, Jens Bollerslev, Roger Bouillon, Felipe F Casanueva, Giulia Martina Cavestro, Marlene Chakhtoura and 19 more

Erratum issuedOpen access · hybridAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Reviews in endocrine & metabolic disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 41 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 3 pooled it
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors at 20 institutions in 10 countries.

Andrea GiustinaInstitute of Endocrine and Metabolic Sciences, Università Vita-Salute San Raffaele, IRCCS Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy. giustina.andrea@hsr.it.ORCID http://orcid.org/0000-0001-6783-3398
Luigi di FilippoInstitute of Endocrine and Metabolic Sciences, Università Vita-Salute San Raffaele, IRCCS Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy.ORCID http://orcid.org/0009-0002-6117-0081
Antonio FacciorussoDepartment of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.ORCID http://orcid.org/0000-0002-2107-2156
Robert A AdlerRichmond Veterans Affairs Medical Center and Virginia Commonwealth University, Richmond, VA, USA.ORCID http://orcid.org/0000-0002-2019-0417
Neil BinkleyUniversity of Wisconsin-Madison, Madison, USA.ORCID http://orcid.org/0000-0002-9905-461X
Jens BollerslevFaculty of Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-0654-4610
Roger BouillonLaboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, 3000 KU, Leuven, Belgium.ORCID http://orcid.org/0000-0002-6446-3763
Felipe F CasanuevaMolecular Endocrinology Group, Instituto de Investigacion Sanitaria (IDIS), Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS). CIBER de Fisiopatologia de La Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0002-9052-8161
Giulia Martina CavestroGastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0003-1947-9368
Marlene ChakhtouraCalcium Metabolism and Osteoporosis Program, American University of Beirut-Medical Center, Beirut, Lebanon.ORCID http://orcid.org/0000-0003-0012-986X
Caterina ConteDepartment of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Via Di Val Cannuta 247, 00166, Rome, Italy.ORCID http://orcid.org/0000-0001-7066-5292
Lorenzo M DoniniExperimental Medicine Department, Sapienza University, Rome, Italy.ORCID http://orcid.org/0000-0003-4692-4754
Peter R EbelingDepartment of Medicine, School of Clinical Sciences, Monash University, Clayton, Australia.ORCID http://orcid.org/0000-0002-2921-3742
Angelo FassioRheumatology Unit, University of Verona, Verona, Italy.ORCID http://orcid.org/0000-0001-9187-232X
Stefano FraraInstitute of Endocrine and Metabolic Sciences, Università Vita-Salute San Raffaele, IRCCS Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy.ORCID http://orcid.org/0000-0002-1308-5598
Claudia GagnonDepartment of Medicine, Université Laval, Quebec City, Canada.ORCID http://orcid.org/0000-0001-9623-962X
Giovanni LatellaGastroenterology, Hepatology and Nutrition Division, Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.ORCID http://orcid.org/0000-0001-6341-5711
Claudio MarcocciDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.ORCID http://orcid.org/0000-0001-6568-8588
Jeffrey I MechanickKravis Center for Clinical Cardiovascular Health at Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.ORCID http://orcid.org/0000-0002-0657-588X
Salvatore MinisolaSapienza Rome University, Rome, Italy.ORCID http://orcid.org/0000-0001-6525-0439
René RizzoliService of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.ORCID http://orcid.org/0000-0002-1537-422X
Ferruccio SantiniObesity and Lipodystrophy Center, University Hospital of Pisa, Pisa, Italy.ORCID http://orcid.org/0000-0002-1706-0822
Joseph L ShakerDepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0002-6266-1029
Christopher SemposVitamin D Standardization Program, Havre de Grace, MD, USA.ORCID http://orcid.org/0000-0003-1324-3282
Fabio Massimo UlivieriInstitute of Endocrine and Metabolic Sciences, Università Vita-Salute San Raffaele, IRCCS Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy.ORCID http://orcid.org/0000-0003-1357-3425
Jyrki K VirtanenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0002-0648-999X
Nicola NapoliDepartment of Medicine and Surgery, Research Unit of Endocrinology and Diabetes, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21 - 00128, Roma, Italy.ORCID http://orcid.org/0000-0002-3091-8205
Anne L SchaferUniversity of California, San Francisco and the San Francisco Veterans Affairs Health Care System, San Francisco, USA.ORCID http://orcid.org/0000-0002-4750-9125
John P BilezikianDepartment of Medicine, Endocrinology Division, Vagelos College of Physicians and Surgeons Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-1570-2617
Vita-Salute San Raffaele University · ITSapienza University of Rome · ITAmerican University of Beirut Medical Center · LBAzienda Ospedaliera Universitaria Pisana · ITColumbia University · USGrace (United States) · USIcahn School of Medicine at Mount Sinai · USInstituto de Salud Carlos III · ESKU Leuven · BEMedical College of Wisconsin · USMonash University · AUSan Raffaele University of Rome · ITUniversità Campus Bio-Medico · ITUniversité Laval · CAUniversity Hospital of Geneva · CHUniversity of California, San Francisco · USUniversity of Eastern Finland · FIUniversity of Foggia · ITUniversity of L'Aquila · ITUniversity of Oslo · NO

Funding

UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
NIDDK NIH HHS P30 DK098722
6 · The paper itself

Abstract

Bariatric surgery is associated with a postoperative reduction of 25(OH) vitamin D levels (25(OH)D) and with skeletal complications. Currently, guidelines for 25(OH)D assessment and vitamin D supplementation in bariatric patients, pre- and post-surgery, are still lacking. The aim of this work is to analyse systematically the published experience on 25(OH)D status and vitamin D supplementation, pre- and post-surgery, and to propose, on this basis, recommendations for management. Preoperatively, 18 studies including 2,869 patients were evaluated. Prevalence of vitamin D insufficiency as defined by 25(OH)D < 30 ng/mL (75 nmol/L) was 85%, whereas when defined by 25(OH)D < 20 ng/mL (50 nmol/L) was 57%. The median preoperative 25(OH)D level was 19.75 ng/mL. After surgery, 39 studies including 5,296 patients were analysed and among those undergoing either malabsorptive or restrictive procedures, a lower rate of vitamin D insufficiency and higher 25(OH)D levels postoperatively were observed in patients treated with high-dose oral vitamin D supplementation, defined as ≥ 2,000 IU/daily (mostly D3-formulation), compared with low-doses (< 2,000 IU/daily). Our recommendations based on this systematic review and meta-analysis should help clinical practice in the assessment and management of vitamin D status before and after bariatric surgery. Assessment of vitamin D should be performed pre- and postoperatively in all patients undergoing bariatric surgery. Regardless of the type of procedure, high-dose supplementation is recommended in patients after bariatric surgery.

Indexed as

Bariatric SurgeryVitamin D DeficiencyDietary SupplementsHumansVitamin DVitaminsVitamin DVitaminsBariatric surgeryObesityVitamin D assayVitamin D insufficiencyVitamin D supplementation

Identifiers

PMID37665480
PMCPMC10698146
OpenAlexW4386408109

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.