Evidence map›Paper›PMID 37665448›Full record

Trial reportInflammopharmacology2023

The effect of magnesium sulfate on gene expression and serum level of inflammatory cytokines in coronary artery disease patients.

Fatemeh Mohebi, Samane Ostadhadi, Mohammad Sadegh Vaziri, Marziyeh Hassanzadeh, Shabnaz Koochakkhani, Fariba Azarkish, Hossein Farshidi, Ebrahim Eftekhar

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Inflammopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Methylglyoxal Formation-Metabolic Routes and Consequences.Antioxidants (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Fatemeh MohebiMolecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.ORCID http://orcid.org/0000-0002-7926-9496
Samane OstadhadiCardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Mohammad Sadegh VaziriMolecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Marziyeh HassanzadehMolecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.ORCID http://orcid.org/0000-0003-1528-0116
Shabnaz KoochakkhaniMolecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.ORCID http://orcid.org/0000-0002-4514-3465
Fariba AzarkishMolecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.ORCID http://orcid.org/0000-0001-5575-4772
Hossein FarshidiCardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.ORCID http://orcid.org/0000-0002-2144-7798
Ebrahim EftekharMolecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. eftekhar19@gmail.com.ORCID http://orcid.org/0000-0002-4519-0595
Hormozgan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the effect of oral magnesium sulfate (MgSO

methods60 CAD patients were selected based on angiography findings and were randomly divided into two groups that received 300 mg/day MgSO

resultsAfter 3 months of intervention, gene expression and serum levels of IL-18 and TNF-α in the MgSO

conclusionThe results of our study demonstrate that 3-month magnesium sulfate administration (300 mg/day) to CAD patients could significantly decrease serum concentration and gene expression levels of IL-18 and TNF-α. Our findings support the potential beneficial effect of magnesium supplementation on alleviating CAD complications through modulating inflammatory cytokines.

Indexed as

Coronary Artery DiseaseCytokinesGene ExpressionHumansInterleukin-18Interleukin-6Magnesium SulfateTumor Necrosis Factor-alphaCytokinesInterleukin-18Interleukin-6Magnesium SulfateTumor Necrosis Factor-alphaCoronary artery diseaseInflammatory cytokinesMagnesium sulfate

Identifiers

PMID37665448
OpenAlexW4386407069

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.