Evidence map›Paper›PMID 37665414›Full record

ArticleParasitology research2023

The anti-amoebic potential of carboxamide derivatives containing sulfonyl or sulfamoyl moieties against brain-eating Naegleria fowleri.

Noor Akbar, Ruqaiyyah Siddiqui, Mohammed I El-Gamal, Seyed-Omar Zaraei, Bader S Alawfi, Naveed Ahmed Khan

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In one paragraph

Article in Parasitology research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Noor AkbarResearch Institute of Medical and Health Sciences, University of Sharjah, University City, Sharjah, 27272, United Arab Emirates.
Ruqaiyyah SiddiquiCollege of Arts and Sciences, American University of Sharjah, University City, Sharjah, 26666, United Arab Emirates.
Mohammed I El-GamalResearch Institute of Medical and Health Sciences, University of Sharjah, University City, Sharjah, 27272, United Arab Emirates. drmelgamal2002@gmail.com.
Seyed-Omar ZaraeiResearch Institute of Medical and Health Sciences, University of Sharjah, University City, Sharjah, 27272, United Arab Emirates.
Bader S AlawfiDepartment of Medical Laboratories Technology, College of Applied Medical Sciences, Taibah University, Madinah, 42353, Saudi Arabia.
Naveed Ahmed KhanMicrobiota Research Center, Istinye University, 34010, Istanbul, Turkey. naveed5438@gmail.com.
University of Sharjah · AEAmerican University of Sharjah · AEIstinye University · TRTaibah University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Naegleria fowleri is a free-living thermophilic flagellate amoeba that causes a rare but life-threatening infection called primary amoebic meningoencephalitis (PAM), with a very high fatality rate. Herein, the anti-amoebic potential of carboxamide derivatives possessing sulfonyl or sulfamoyl moiety was assessed against pathogenic N. fowleri using amoebicidal, cytotoxicity and cytopathogenicity assays. The results from amoebicidal experiments showed that derivatives dramatically reduced N. fowleri viability. Selected derivatives demonstrated IC

Indexed as

AmebicidesAmoebaCentral Nervous System Protozoal InfectionsNaegleria fowleriBrainEndothelial CellsHumansAmebicidesAmoebicidalCarboxamideCytopathogenicityNaegleria fowleriPrimary amoebic meningoencephalitisSulfamoylSulfonyl

Identifiers

PMID37665414
OpenAlexW4386407195

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.