Evidence map›Paper›PMID 37665123›Full record

ArticleeLife2023

Id2 GABAergic interneurons comprise a neglected fourth major group of cortical inhibitory cells.

Robert Machold, Shlomo Dellal, Manuel Valero, Hector Zurita, Ilya Kruglikov, John Hongyu Meng, Jessica L Hanson, Yoshiko Hashikawa, Benjamin Schuman, György Buzsáki and 1 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Neuropeptidergic systems in psychiatric disorders.Frontiers in endocrinology · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Cell-Type-Specific Effects of Somatostatin on Synaptic Transmission in the Anterior Cingulate Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  13. Article
  14. Review
  15. Article
  16. Article
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  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Robert MacholdNeuroscience Institute, New York University Grossman School of Medicine, New York, United States.ORCID 0000-0002-6261-496X
Shlomo Dellal *Neuroscience Institute, New York University Grossman School of Medicine, New York, United States.
Manuel Valero *Neuroscience Institute, New York University Grossman School of Medicine, New York, United States.
Hector ZuritaNeuroscience Institute, New York University Grossman School of Medicine, New York, United States.
Ilya KruglikovNeuroscience Institute, New York University Grossman School of Medicine, New York, United States.
John Hongyu MengNeuroscience Institute, New York University Grossman School of Medicine, New York, United States.
Jessica L HansonNeuroscience Institute, New York University Grossman School of Medicine, New York, United States.
Yoshiko HashikawaNeuroscience Institute, New York University Grossman School of Medicine, New York, United States.
Benjamin SchumanNeuroscience Institute, New York University Grossman School of Medicine, New York, United States.
György BuzsákiNeuroscience Institute, New York University Grossman School of Medicine, New York, United States.ORCID 0000-0002-3100-4800
Bernardo RudyNeuroscience Institute, New York University Grossman School of Medicine, New York, United States.ORCID 0000-0003-1367-7136
New York University · US

Funding

U19 Supplement 2023-FroemkeU19NS107616 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RICHARD W TSIEN · 2018 to 2026
$36.4M
The role of genetic and activity dependent cues in the generation of 5HT3aR interneuron diversityP01NS074972 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MACHOLD, ROBERT P · 2012 to 2023
$15.5M
Spatiotemporal control of dendritic inhibition by a family of diverse somatostatin-expressing interneuronsR01NS110079 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RUDY, BERNARDO · 2018 to 2022
$3.0M
Inhibitory and Disinhibitory VIP Interneuron-Mediated Circuits in NeocortexR01NS133751 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Bernardo Rudy · 2023 to 2026
$2.6M
Layer 4 circuits and sensory processingR01NS107257 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RUDY, BERNARDO · 2018 to 2022
$2.1M
NIH HHS P01NS074972NIH HHS R01NS110079NIH HHS U19NS107616NINDS NIH HHS P01 NS074972NINDS NIH HHS R01 NS107257NINDS NIH HHS R01 NS110079NINDS NIH HHS R01 NS133751NINDS NIH HHS U19 NS107616
6 · The paper itself

Abstract

Cortical GABAergic interneurons (INs) represent a diverse population of mainly locally projecting cells that provide specialized forms of inhibition to pyramidal neurons and other INs. Most recent work on INs has focused on subtypes distinguished by expression of Parvalbumin (PV), Somatostatin (SST), or Vasoactive Intestinal Peptide (VIP). However, a fourth group that includes neurogliaform cells (NGFCs) has been less well characterized due to a lack of genetic tools. Here, we show that these INs can be accessed experimentally using intersectional genetics with the gene

Indexed as

GABAergic NeuronsInterneuronsNeuropeptidesInhibitor of Differentiation Protein 2Neuropeptide YParvalbuminsPyramidal CellsVasoactive Intestinal PeptideIdb2 protein, mouseInhibitor of Differentiation Protein 2NeuropeptidesNeuropeptide YParvalbuminsVasoactive Intestinal Peptidecortical inhibitionGABAergic InterneuronsId2intersectional geneticsin vivo recordingsmouseneurogliaform cellsneuroscience

Identifiers

PMID37665123
PMCPMC10581691
OpenAlexW4386407749

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.