Evidence map›Paper›PMID 37664794›Full record

ArticleMaterials today. Bio2023

Engineering choroid plexus-on-a-chip with oscillatory flow for modeling brain metastasis.

Jungeun Lim, Stephen Rhee, Hyeri Choi, Jungseub Lee, Shruthy Kuttappan, Tri Tho Yves Nguyen, Sunbeen Choi, YongTae Kim, Noo Li Jeon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
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  3. Cancer metastasisFrontiers in bioengineering and biotechnology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Jungeun LimSchool of Mechanical Engineering, Seoul National University, Seoul, 08826, South Korea.
Stephen RheeSchool of Mechanical Engineering, Seoul National University, Seoul, 08826, South Korea.
Hyeri ChoiInterdisciplinary Program in Bioengineering, Seoul National University, Seoul, 08826, South Korea.
Jungseub LeeSchool of Mechanical Engineering, Seoul National University, Seoul, 08826, South Korea.
Shruthy KuttappanInstitute of Advanced Machinery and Design, Seoul National University, Seoul, 08826, South Korea.
Tri Tho Yves NguyenSchool of Mechanical Engineering, Seoul National University, Seoul, 08826, South Korea.
Sunbeen ChoiSchool of Mechanical Engineering, Seoul National University, Seoul, 08826, South Korea.
YongTae KimGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, North Ave NW, Atlanta, GA, 30332, USA.
Noo Li JeonSchool of Mechanical Engineering, Seoul National University, Seoul, 08826, South Korea.
Seoul National University · KRGeorgia Institute of Technology · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human brain choroid plexus (ChP) is a highly organized secretory tissue with a complex vascular system and epithelial layers in the ventricles of the brain. The ChP is the body's principal source of cerebrospinal fluid (CSF); it also functions as a barrier to separate the blood from CSF, because the movement of CSF through the body is pulsatile in nature. Thus far, it has been challenging to recreate the specialized features and dynamics of the ChP in a physiologically relevant microenvironment. In this study, we recapitulated the ChP structure by developing a microfluidic chip in accordance with established design rules. Furthermore, we used image processing and analysis to mimic CSF flow dynamics within a rlcking system; we also used a hydrogel containing laminin to mimic brain extracellular matrix (ECM). Human ChP cells were cultured in the ChP-on-a-chip with

Indexed as

Brain metastasisCerebrospinal fluid dynamicsChoroid plexusOrgan-on-a-chipTumor-immune microenvironment

Identifiers

PMID37664794
PMCPMC10474164
OpenAlexW4385973402

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.