ArticleiScience2023
Hematopoietic stem and progenitor cells confer cross-protective trained immunity in mouse models.
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Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 36 papers.
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36citing papers in PubMed
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Who cites it
36 citing papers in PubMed.
- Loss of Function Dnmt3a Mutation Leads to Aberrant Neutrophil Migration.Experimental hematology · 2026Article
- HIV-1 Nef generates lasting innate immune memory in haematopoietic stem and progenitor cells in vivo.EMBO reports · 2026Article
- Tissue context as a determinant of trained innate immunity: a conserved molecular toolkit with divergent functional outputs.Journal of leukocyte biology · 2026Review
- InactivatedVaccines · 2026Article
- Trained immunity: new paradigm in the immunological memory of cardiovascular disease.ImmunoHorizons · 2026Review
- Challenge Specific Modulation of Responses to Adjuvant-Induced Innate Immune Memory.Immunology · 2026Article
- Rare epigenetic alterations are conserved across hematopoietic differentiation stages after mycobacterial infection.JCI insight · 2026Article
- An inflammatory and quiescent HSC subpopulation expands with age in humans.Genome biology · 2026Article
- The potential role of trained immunity in HIV-associated atherosclerotic cardiovascular disease: mechanisms and therapeutic implications.Frontiers in immunology · 2026Review
- Prior Exposure of Airway Epithelial Cells to Mycobacteria Reduces Subsequent <italic>Mycobacterium tuberculosis</italic> Infection and Resulting Inflammation.Journal of innate immunity · 2026Article
- ACK2 antibody conditioning enhances adoptive transfer of hematopoietic progenitors to study central trained immunity in mice.Frontiers in immunology · 2026Article
- Examining the Interaction between Allergic Asthma and Air Pollution: a Potential Role for Trained Immunity.Current allergy and asthma reports · 2025Review
- How stem cells respond to infection, inflammation and ageing.Nature reviews. Immunology · 2025Review
- Mechanisms of Innate Immune Modulation by High-Fat Diet: Implications for Obesity and Asthma.Current allergy and asthma reports · 2025Review
- Ageing, immune fitness and cancer.Nature reviews. Cancer · 2025Review
- Trained immunity: induction of an inflammatory memory in disease.Cell research · 2025Review
- A unified multimodal single-cell framework reveals a discrete state model of hematopoiesis in mice.Nature immunology · 2025Article
- Rewiring the bone marrow: Evolution and the transcriptional architecture of trained immunity.eLife · 2025Review
- Trained immunity induced by DAMPs and LAMPs in chronic inflammatory diseases.Experimental & molecular medicine · 2025Review
- An Inflammatory and Quiescent HSC Subpopulation Expands with Age in Humans.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
16 authors.
Bailee N KainGraduate Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX, USA.
Brandon T TranDepartment of Pediatrics - Division of Infectious Disease, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
Pamela N LunaDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Ruoqiong CaoDepartment of Pediatrics - Division of Infectious Disease, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
Duy T LeDepartment of Pediatrics - Division of Infectious Disease, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
Marcus A FlorezGraduate Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX, USA.
Laure ManeixHuffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.
Jack D ToupsDepartment of Pediatrics - Division of Infectious Disease, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
Daniel E Morales-MantillaDepartment of Pediatrics - Division of Infectious Disease, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
Scott KohDepartment of Pediatrics - Division of Infectious Disease, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
Hyojeong HanDepartment of Pediatrics - Division of Hematology Oncology, Baylor College of Medicine, Houston, TX, USA.
Roman JaksikDepartment of Systems Biology and Engineering and Biotechnology Centre, Silesian University of Technology, 44-100 Gliwice, Poland.
Yun HuangCenter for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M Health, Houston, TX, USA.
Andre CaticHuffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.
Chad A ShawDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Katherine Y KingGraduate Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX, USA.
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9MVISION RESEARCH CENTERP30EY002520 · NEI · BAYLOR COLLEGE OF MEDICINE · PI Samuel M Wu · 1985 to 2026
$14.8MProject 3: Contribution of inflammation and DNA damaging factors to clonal expansion and malignant transformation in a community cohort of older adultsP01CA265748 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Daisuke Nakada · 2022 to 2026
$13.6MHematology Training ProgramT32DK060445 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI GOODELL, MARGARET A. · 2002 to 2023
$8.3MTraining In Cell and Gene TherapyT32HL092332 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI MALCOLM K. BRENNER, Bruno Di Stefano · 2008 to 2026
$6.9MImpact of Infection and Inflammation on Primitive HematopoiesisR35HL155672 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Katherine Yudeh King · 2021 to 2026
$5.1MImmunology Scientist Training ProgramT32AI053831 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI CORRY, DAVID B · 2003 to 2018
$4.2MMicrobiota-dependent regulation of primitive hematopoiesesR01AI141716 · NIAID · WASHINGTON UNIVERSITY · PI BALDRIDGE, MEGAN T · 2019 to 2023
$2.3MThe Contribution ofInfection to Preleukemic Clonal HematopoiesisR01HL136333 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI KING, KATHERINE YUDEH · 2017 to 2020
$1.9MTranscript decay regulates hematopoietic agingR01DK115454 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI CATIC, ANDRE · 2017 to 2021
$1.8MInflammatory Regulation of Hematopoietic Stem and Progenitor Cells to Enhance Innate ImmunityR01HL134880 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI KING, KATHERINE YUDEH · 2017 to 2020
$1.6MHigh Throughput Genomic Sequencer at BCM Core FacilityS10OD023469 · OD · BAYLOR COLLEGE OF MEDICINE · PI CHEN, RUI · 2017 to 2017
$600kNCI NIH HHS P01 CA265748NCI NIH HHS P30 CA125123NCRR NIH HHS S10 RR024574NEI NIH HHS P30 EY002520NHLBI NIH HHS F31 HL164287NHLBI NIH HHS R01 HL134880NHLBI NIH HHS R01 HL136333NHLBI NIH HHS R35 HL155672NHLBI NIH HHS T32 HL092332NIAID NIH HHS R01 AI141716NIAID NIH HHS T32 AI053831NIDDK NIH HHS R01 DK115454NIDDK NIH HHS T32 DK060445NIH HHS S10 OD023469NIH HHS S10 OD025240
Abstract
Recent studies suggest that infection reprograms hematopoietic stem and progenitor cells (HSPCs) to enhance innate immune responses upon secondary infectious challenge, a process called "trained immunity." However, the specificity and cell types responsible for this response remain poorly defined. We established a model of trained immunity in mice in response to
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Cell biologyImmunologyMicrobiologyStem cells researchTranscriptomics
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.