Evidence map›Paper›PMID 37664456›Full record

ReviewIntegrative medicine research2023

Curcumin, inflammation, and neurological disorders: How are they linked?

Prachi Garodia, Mangala Hegde, Ajaikumar B Kunnumakkara, Bharat B Aggarwal

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Integrative medicine research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Prachi GarodiaIntegrative Research Center, Miami, FL, USA.
Mangala HegdeDepartment of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, India.
Ajaikumar B KunnumakkaraDepartment of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, India.
Bharat B AggarwalInflammation Research Center, San Diego, CA, USA.
Indian Institute of Technology Guwahati · INInflammation Research Foundation · USIntegrative Medicine Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Despite the extensive research in recent years, the current treatment modalities for neurological disorders are suboptimal. Curcumin, a polyphenol found in Methods: We searched PubMed database for relevant publications on curcumin and its uses in treating neurological diseases. We also reviewed relevant clinical trials which appeared on searching PubMed database using 'Curcumin and clinical trials'. Results: This review details the pleiotropic immunomodulatory functions and neuroprotective properties of curcumin, its derivatives and formulations in various preclinical and clinical investigations. The effects of curcumin on neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), brain tumors, epilepsy, Huntington's disorder (HD), ischemia, Parkinson's disease (PD), multiple sclerosis (MS), and traumatic brain injury (TBI) with a major focus on associated signalling pathways have been thoroughly discussed. Conclusion: This review demonstrates curcumin can suppress spinal neuroinflammation by modulating diverse astroglia mediated cascades, ensuring the treatment of neurological disorders.

Indexed as

Alzheimer's diseaseCurcuminInflammationNeurological disordersParkinson's disease

Identifiers

PMID37664456
PMCPMC10469086
OpenAlexW4381951097

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.