Evidence map›Paper›PMID 37664206›Full record

ArticleRSC advances2023

Fabrication of ACP-CCS-PVA composite membrane for a potential application in guided bone regeneration.

Qiaolin Du, Jian Sun, Yanyan Zhou, Yadong Yu, Weijing Kong, Chaoqun Chen, Yifeng Zhou, Ke Zhao, Changyu Shao, Xinhua Gu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. [Advances in Molecular Regulatory Mechanisms of Jaw Repair and Reconstruction].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Qiaolin DuDepartment of Stomatology, The First Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou 310003 China guxh@zju.edu.cn.
Jian SunDepartment of Stomatology, The First Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou 310003 China guxh@zju.edu.cn.
Yanyan ZhouStomatology Hospital, School of Stomatology, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Zhejiang University School of Medicine Hangzhou 310006 China.
Yadong YuDepartment of Chemistry, Zhejiang University Hangzhou Zhejiang 310027 China.
Weijing KongStomatology Hospital, School of Stomatology, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Zhejiang University School of Medicine Hangzhou 310006 China.
Chaoqun ChenDepartment of Stomatology, The First Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou 310003 China guxh@zju.edu.cn.
Yifeng ZhouDepartment of Stomatology, The First Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou 310003 China guxh@zju.edu.cn.
Ke ZhaoDepartment of Stomatology, The First Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou 310003 China guxh@zju.edu.cn.
Changyu ShaoStomatology Hospital, School of Stomatology, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Zhejiang University School of Medicine Hangzhou 310006 China.ORCID https://orcid.org/0000-0001-8191-0871
Xinhua GuDepartment of Stomatology, The First Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou 310003 China guxh@zju.edu.cn.ORCID https://orcid.org/0000-0001-6674-1803
Zhejiang University · CNStomatology Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The barrier membranes of guided bone regeneration (GBR) have been widely used in clinical medicine to repair bone defects. However, the unmatched mechanical strength, unsuitable degradation rates, and insufficient regeneration potential limit the application of the current barrier membranes. Here, amorphous calcium phosphate-carboxylated chitosan-polyvinyl alcohol (ACP-CCS-PVA) composite membranes are fabricated by freeze-thaw cycles, in which the ATP-stabilized ACP nanoparticles are uniformly distributed throughout the membranes. The mechanical performance and osteogenic properties are significantly improved by the ACP incorporated into the CCS-PVA system, but excess ACP would suppress cell proliferation and osteogenic differentiation. Our work highlights the pivotal role of ACP in GBR and provides insight into the need for biomaterial fabrication to balance mechanical strength and mineral content.

Identifiers

PMID37664206
PMCPMC10472212
OpenAlexW4386382269

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.