Evidence map›Paper›PMID 37663790›Full record

ArticleWellcome open research2023

Predicting Acute and Post-Recovery Outcomes in Cerebral Malaria and Other Comas by Optical Coherence Tomography (OCT in CM) - A protocol for an observational cohort study of Malawian children.

Kyle J Wilson, Zhanhan Tu, Emmie Mbale, Priscilla P Mhango, Petros Kayange, Melissa J Gladstone, Simon Harding, Irene Gottlob, Marta Garcia-Finana, Yaochun Shen and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Wellcome open research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Malaria: past, present, and future.Signal transduction and targeted therapy · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Kyle J WilsonEye & Vision Science, University of Liverpool, Liverpool, England, L69 7TX, UK.ORCID https://orcid.org/0000-0003-0151-7530
Zhanhan TuUlverscroft Eye Unit, University of Leicester, Leicester, England, LE2 7LX, UK.
Emmie MbaleDepartment of Paediatrics, Kamuzu University of Health Sciences, Blantyre, Southern Region, P/Bag 360, Malawi.
Priscilla P MhangoDepartment of Ophthalmology, Kamuzu University of Health Sciences, Blantyre, Southern Region, P/Bag 360, Malawi.ORCID https://orcid.org/0000-0003-4129-8379
Petros KayangeDepartment of Ophthalmology, Kamuzu University of Health Sciences, Blantyre, Southern Region, P/Bag 360, Malawi.ORCID https://orcid.org/0000-0003-1085-2584
Melissa J GladstoneWomen's and Children's Health, University of Liverpool, Liverpool, England, L69 7TX, UK.ORCID https://orcid.org/0000-0002-2579-9301
Simon HardingEye & Vision Science, University of Liverpool, Liverpool, England, L69 7TX, UK.
Irene GottlobCooper Neurological Institute, Cherry Hill, New Jersey, 08002, USA.
Marta Garcia-FinanaDepartment of Health Data Science, University of Liverpool, Liverpool, England, L69 3GF, UK.
Yaochun ShenDepartment of Electrical Engineering and Electronics, University of Liverpool, Liverpool, England, L69 3GJ, UK.
Terrie E TaylorCollege of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, 4882, USA.
Karl B SeydelCollege of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, 4882, USA.ORCID https://orcid.org/0000-0001-9859-9549
Yalin ZhengEye & Vision Science, University of Liverpool, Liverpool, England, L69 7TX, UK.
Nicholas Av BeareEye & Vision Science, University of Liverpool, Liverpool, England, L69 7TX, UK.ORCID https://orcid.org/0000-0001-8086-990X
University of Liverpool · GBMalawi University of Science and Technology · MWBlantyre Institute for Community Ophthalmology · MWCooper Institute · USUlverscroft (United Kingdom) · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Cerebral malaria (CM) remains a significant global health challenge with high morbidity and mortality. Malarial retinopathy has been shown to be diagnostically and prognostically significant in the assessment of CM. The major mechanism of death in paediatric CM is brain swelling. Long term morbidity is typically characterised by neurological and neurodevelopmental sequelae. Optical coherence tomography can be used to quantify papilloedema and macular ischaemia, identified as hyperreflectivity. Here we describe a protocol to test the hypotheses that quantification of optic nerve head swelling using optical coherence tomography can identify severe brain swelling in CM, and that quantification of hyperreflectivity in the macula predicts neurodevelopmental outcomes post-recovery. Additionally, our protocol includes the development of a novel, low-cost, handheld optical coherence tomography machine and artificial intelligence tools to assist in image analysis.

Indexed as

artificial intelligencebrain swellingcerebral malariaintracranial pressuremalarial retinopathyoptical coherence tomography

Identifiers

PMID37663790
PMCPMC10468659
OpenAlexW4365504493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.