ArticleACS omega2023
Recombinant Collagen-Templated Biomineralized Synthesis of Biocompatible pH-Responsive Porous Calcium Carbonate Nanospheres.
Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Scalable Synthesis of Calcium Fluoride Nanoparticles as a Novel Ultrasound Contrast Agent for Imaging Tumor Targeted Delivery of Therapeutics.Chemical & biomedical imaging · 2026Article
- Biowaste-Archetyped Hierarchical Calcium Carbonate Nanoreactors Induce Tumor Bioenergetic Crisis and Reverse Cisplatin Resistance via Mitochondrial Metabolic Reprogramming.ACS applied materials & interfaces · 2026Article
- Calcium-enriched mesoporous silica/PLGA scaffolds enhance bone repair in a rabbit femoral condylar defect model.Scientific reports · 2026Article
- Novel crosslinked recombinant human collagen scaffolds with excellent cytocompatibility and wound healing effect.RSC advances · 2025Article
- Sustainable Hydrogels for Medical Applications: Biotechnological Innovations Supporting One Health.Gels (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The synthesis of calcium carbonate with controlled morphology is crucial for its biomedical applications. In this study, we synthesized well-ordered porous calcium carbonate nanospheres using recombinant collagen as a biomineralization template. Porous collagen-calcium carbonate was created by incubating calcium chloride and sodium carbonate with collagen biotemplates at room temperature. Our results show that the recombinant collagen-calcium carbonate nanomaterials underwent a morphological transition from solid nanospheres to more porous nanospheres and a phase transformation from vaterite to a mixture of calcite and vaterite. This study highlights the crucial role of recombinant collagen in modulating the morphology and crystallinity of calcium carbonate nanoparticles. Importantly, the highly porous recombinant collagen-calcium carbonate hybrid nanospheres demonstrated superior loading efficacy for the model drug cefoperazone. Furthermore, the drug loading and releasing results suggest that hybrid nanospheres have the potential to be robust and biocompatible pH-responsive drug carriers. Our findings suggest that recombinant collagen's unique amino acid content and rodlike structure make it a superior template for biomineralized synthesis. This study provides a promising avenue for the production of novel organic-inorganic nanostructures, with potential applications in biomedical fields such as drug delivery.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.