Evidence map›Paper›PMID 37663141›Full record

ArticleFrontiers in chemistry2023

Multicomponent synthesis and photophysical study of novel α,β-unsaturated carbonyl depsipeptides and peptoids.

Ricelia González, Juliana Murillo-López, Walter Rabanal-León, Luis Prent-Peñaloza, Odette Concepción, Pedro Olivares, Yorley Duarte, Alexander F de la Torre, Margarita Gutiérrez, Julio Caballero

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ricelia GonzálezDoctorado en Ciencias Mención I + D de Productos Bioactivos, Laboratorio de Síntesis Orgánica y Actividad Biológica, Instituto de Química de Recursos Naturales, Universidad de Talca, Talca, Chile.
Juliana Murillo-LópezDepartamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Concepción, Concepción, Chile.
Walter Rabanal-LeónDepartamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Concepción, Concepción, Chile.
Luis Prent-PeñalozaDepartamento de Ciencias Químicas, Facultad de Ciencias Exactas, Universidad Andrés Bello, Viña del Mar, Chile.
Odette ConcepciónDepartamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Concepción, Concepción, Chile.
Pedro OlivaresCentro de Bioinformática y Biología Integrativa, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago, Chile.
Yorley DuarteCentro de Bioinformática y Biología Integrativa, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago, Chile.
Alexander F de la TorreDepartamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Concepción, Concepción, Chile.
Margarita GutiérrezLaboratorio de Síntesis Orgánica y Actividad Biológica, Instituto de Química de Recursos Naturales, Universidad de Talca, Talca, Chile.
Julio CaballeroDepartamento de Bioinformática, Facultad de Ingeniería, Centro de Bioinformática, Simulación y Modelado (CBSM), Universidad de Talca, Talca, Chile.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multicomponent reactions were performed to develop novel α,β-unsaturated carbonyl depsipeptides and peptoids incorporating various chromophores such as cinnamic, coumarin, and quinolines. Thus, through the Passerini and Ugi multicomponent reactions (P-3CR and U-4CR), we obtained thirteen depsipeptides and peptoids in moderate to high yield following the established protocol and fundamentally varying the electron-rich carboxylic acid as reactants. UV/Vis spectroscopy was utilized to study the photophysical properties of the newly synthesized compounds. Differences between the carbonyl-substituted chromophores cause differences in electron delocalization that can be captured in the spectra. The near UV regions of all the compounds exhibited strong absorption bands. Compounds

Indexed as

depsipeptidesmulticomponent reactionspeptidomimeticspeptoidstime-dependent density functional theory (TD-DFT)

Identifiers

PMID37663141
PMCPMC10471130

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.