Evidence map›Paper›PMID 37662915›Full record

ReviewFrontiers in immunology2023

Research on the biological mechanism and potential application of CEMIP.

Yang Liu, Gang Hu, Yuetong Li, Xinyi Kong, Kaming Yang, Zhenlin Li, Wanwen Lao, Jiaxin Li, Jianhua Zhong, Shitong Zhang and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Yang LiuDepartment of Laboratory Medicine, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Gang HuThe Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Yuetong LiDepartment of Endocrinology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Xinyi KongDepartment of Laboratory Medicine, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Kaming YangDepartment of Endocrinology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Zhenlin LiDepartment of Endocrinology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Wanwen LaoDepartment of Endocrinology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Jiaxin LiDepartment of Endocrinology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Jianhua ZhongDepartment of Endocrinology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Shitong ZhangDepartment of General Practice, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Yuxin LengDepartment of Critical Care Medicine, Peking University Third Hospital, Beijing, China.
Changlong BiDepartment of Endocrinology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Aixia ZhaiDepartment of Laboratory Medicine, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Eighth Affiliated Hospital of Sun Yat-sen UniversitySun Yat-sen University · CNPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell migration-inducing protein (CEMIP), also known as KIAA1199 and hyaluronan-binding protein involved in hyaluronan depolymerization, is a new member of the hyaluronidase family that degrades hyaluronic acid (HA) and remodels the extracellular matrix. In recent years, some studies have reported that CEMIP can promote the proliferation, invasion, and adhesion of various tumor cells and can play an important role in bacterial infection and arthritis. This review focuses on the pathological mechanism of CEMIP in a variety of diseases and expounds the function of CEMIP from the aspects of inhibiting cell apoptosis, promoting HA degradation, inducing inflammatory responses and related phosphorylation, adjusting cellular microenvironment, and regulating tissue fibrosis. The diagnosis and treatment strategies targeting CEMIP are also summarized. The various functions of CEMIP show its great potential application value.

Indexed as

ArthritisHyaluronic AcidApoptosisCell MovementHumansHyaluronoglucosaminidaseHyaluronic AcidHyaluronoglucosaminidasecell microenvironmentCEMIPfibrosisHApro-inflammatory factortumor

Identifiers

PMID37662915
PMCPMC10471826
OpenAlexW4385996451

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.