Evidence map›Paper›PMID 37662829›Full record

ArticleHeliyon2023

Using x-ray micro computed tomography to quantify intracochlear fibrosis after cochlear implantation in a Guinea pig model.

Kady J Braack, Tylah Miles, Farah Amat, Daniel J Brown, Marcus D Atlas, Jafri Kuthubutheen, Wilhelmina H A M Mulders, Cecilia M Prêle

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Kady J BraackSchool of Human Sciences, University of Western Australia, Crawley, WA 6009, Australia.
Tylah MilesInstitute for Respiratory Health, University of Western Australia, Nedlands, WA 6009, Australia.
Farah AmatSchool of Human Sciences, University of Western Australia, Crawley, WA 6009, Australia.
Daniel J BrownCurtin Medical School, Curtin University, Bentley, WA 6102, Australia.
Marcus D AtlasCurtin Medical School, Curtin University, Bentley, WA 6102, Australia.
Jafri KuthubutheenMedical School, University of Western Australia, Crawley, WA 6009, Australia.
Wilhelmina H A M MuldersSchool of Human Sciences, University of Western Australia, Crawley, WA 6009, Australia.
Cecilia M PrêleInstitute for Respiratory Health, University of Western Australia, Nedlands, WA 6009, Australia.
The University of Western Australia · AUCurtin University · AUMurdoch University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cochlear implants (CIs) allow individuals with profound hearing loss to understand speech and perceive sounds. However, not all patients obtain the full benefits that CIs can provide and the cause of this disparity is not fully understood. One possible factor for the variability in outcomes after cochlear implantation, is the development of fibrotic scar tissue around the implanted electrode. It has been hypothesised that limiting the extent of fibrosis after implantation may improve overall CI function, and longevity of the device. Currently, histology is often used to quantify the extent of intracochlear tissue growth after implantation however this method is labour intensive, time-consuming, often involves significant user bias, and causes physical distortion of the fibrosis. Therefore, this study aimed to evaluate x-ray micro computed tomography (μCT) as a method to measure the amount and distribution of fibrosis in a guinea pig model of cochlear implantation. Adult guinea pigs were implanted with an inactive electrode, and cochleae harvested eight weeks later (n = 7) and analysed using μCT, to quantify the extent of tissue reaction, followed by histological analysis to confirm that the tissue was indeed fibrotic. Cochleae harvested from an additional six animals following implantation were analysed by μCT, before and after contrast staining with osmium tetroxide (OsO

Indexed as

CochleaCochlear implantHearingHistologyInner earOssification

Identifiers

PMID37662829
PMCPMC10474428
OpenAlexW4385997818

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.