Evidence map›Paper›PMID 37662730›Full record

ReviewHeliyon2023

Tumor cell-derived exosomes regulate macrophage polarization: Emerging directions in the study of tumor genesis and development.

Siyuan Tan, Haodong Tang, Yang Wang, Peng Xie, Haifeng Li, Zheng Zhang, Jiahua Zhou

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Siyuan TanDepartment of Surgery, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu Province, China.
Haodong TangDepartment of Surgery, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu Province, China.
Yang WangDepartment of Surgery, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu Province, China.
Peng XieDepartment of Surgery, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu Province, China.
Haifeng LiDepartment of Surgery, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu Province, China.
Zheng ZhangDepartment of Surgery, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu Province, China.
Jiahua ZhouDepartment of Surgery, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu Province, China.
Southeast University · CNZhongda Hospital Southeast University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As an extracellular vesicle, exosomes play an important role in intercellular information transmission, delivering cargos of the parent cell, such as RNA, DNA, proteins, and lipids, activating different signaling pathways in the target cell and regulating inflammation, angiogenesis, and tumor progression. In particular, exosomes secreted by tumor cells can change the function of surrounding cells, creating a microenvironment conducive to tumor growth and metastasis. For example, after macrophages phagocytose exosomes and accept their cargos, they activate macrophage polarization-related signaling pathways and polarize macrophages into M1 or M2 types to exert antitumor or protumor functions. Currently, the study of exosomes affecting the polarization of macrophages has attracted increasing attention. Therefore, this paper reviews relevant studies in this field to better understand the mechanism of exosome-induced macrophage polarization and provide evidence for exploring novel targets for tumor therapy and new diagnostic markers in the future.

Indexed as

ExosomesMacrophage polarizationSignaling pathwaysTumor

Identifiers

PMID37662730
PMCPMC10474436
OpenAlexW4386113098

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.