Evidence map›Paper›PMID 37662421›Full record

ArticlebioRxiv : the preprint server for biology2023

Microglia mediate contact-independent neuronal pruning via secreted Neuraminidase-3 associated with extracellular vesicles.

Corleone S Delaveris, Catherine L Wang, Nicholas M Riley, Sherry Li, Rishikesh U Kulkarni, Carolyn R Bertozzi

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Corleone S DelaverisStanford University, Department of Chemistry and Sarafan ChEM-H, Stanford, CA 94305, USA.
Catherine L WangStanford University, Department of Chemistry and Sarafan ChEM-H, Stanford, CA 94305, USA.
Nicholas M RileyStanford University, Department of Chemistry and Sarafan ChEM-H, Stanford, CA 94305, USA.
Sherry LiStanford University, Department of Chemistry and Sarafan ChEM-H, Stanford, CA 94305, USA.
Rishikesh U KulkarniStanford University, Department of Chemistry and Sarafan ChEM-H, Stanford, CA 94305, USA.
Carolyn R BertozziStanford University, Department of Chemistry and Sarafan ChEM-H, Stanford, CA 94305, USA.
Stanford University · USHoward Hughes Medical Institute · US

Funding

METABOLIC OLIGOSACCHARIDE ENGINEERINGR01GM058867 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Carolyn Bertozzi · 1999 to 2026
$5.6M
Metabolic Engineering with Bioorthogonal Chemical ReportersR37GM058867 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BERTOZZI, CAROLYN · 2009 to 2018
$4.7M
Capturing the Holistic Glycocode through Systems GlycobiologyK99GM147304 · NIGMS · STANFORD UNIVERSITY · PI RILEY, NICHOLAS M · 2022 to 2022
$100k
NIGMS NIH HHS K99 GM147304NIGMS NIH HHS R01 GM058867NIGMS NIH HHS R37 GM058867
6 · The paper itself

Abstract

Neurons communicate with each other through electrochemical transmission at synapses. Microglia, the resident immune cells of the central nervous system, can prune these synapses through a variety of contact-dependent and -independent means. Microglial secretion of active sialidase enzymes upon exposure to inflammatory stimuli is one unexplored mechanism of pruning. Recent work from our lab showed that treatment of neurons with bacterial sialidases disrupts neuronal network connectivity. Here, we find that activated microglia secrete Neuraminidase-3 (Neu3) associated with fusogenic extracellular vesicles. Furthermore, we show Neu3 mediates contact-independent pruning of neurons and subsequent disruption of neuronal networks through neuronal glycocalyx remodeling. We observe that

Indexed as

glycocalyxmicroglianeuraminidaseNeuraminidase-3neuroinflammationneuronal networkneuronsvoltage imaging

Identifiers

PMID37662421
PMCPMC10473657
OpenAlexW4386051174

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.