ArticlebioRxiv : the preprint server for biology2024
Homeostatic regulation of REM sleep by the preoptic area of the hypothalamus.
John Maurer, Alex Lin, Xi Jin, Jiso Hong, Nicholas Sathi, Romain Cardis, Alejandro Osorio-Forero, Anita Lüthi, Franz Weber, Shinjae Chung
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
10 authors.
John MaurerDepartment of Neuroscience, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-2710-1963 Alex LinDepartment of Neuroscience, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Xi JinDepartment of Neuroscience, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-9346-8694 Jiso HongDepartment of Neuroscience, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-8999-7211 Nicholas SathiDepartment of Neuroscience, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Romain CardisDepartment of Fundamental Neurosciences, University of Lausanne, Rue du Bugnon 9, CH-1005 Lausanne, Switzerland.
Alejandro Osorio-ForeroDepartment of Fundamental Neurosciences, University of Lausanne, Rue du Bugnon 9, CH-1005 Lausanne, Switzerland.
Anita LüthiDepartment of Fundamental Neurosciences, University of Lausanne, Rue du Bugnon 9, CH-1005 Lausanne, Switzerland.
Franz WeberDepartment of Neuroscience, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-4541-4907 Shinjae ChungDepartment of Neuroscience, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-2268-563X Funding
Sleep control by the preoptic area of the hypothalamusR01NS110865 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI CHUNG, SHINJAE · 2019 to 2023
$1.8MNeuronal and homeostatic regulation of sleep by the preoptic area and tuberomammillary nucleusF31NS118963 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MAURER, JOHN · 2021 to 2023
$109kNINDS NIH HHS F31 NS118963NINDS NIH HHS R01 NS110865
6 · The paper itselfAbstract
Rapid-eye-movement sleep (REMs) is characterized by activated electroencephalogram (EEG) and muscle atonia, accompanied by vivid dreams. REMs is homeostatically regulated, ensuring that any loss of REMs is compensated by a subsequent increase in its amount. However, the neural mechanisms underlying the homeostatic control of REMs are largely unknown. Here, we show that GABAergic neurons in the preoptic area of the hypothalamus projecting to the tuberomammillary nucleus (POA
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PMID37662417
PMCPMC10473649
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